Piperidin-2-imine

Base Information

• Chemical Name: Piperidin-2-imine
• CAS No.: 22780-54-7
• Molecular Formula: C5H10N2
• Molecular Weight: 98.1478
• DSSTox Substance ID: DTXSID40275816
• Nikkaji Number: J221.238B
• Wikidata: Q27453028
• Pharos Ligand ID: MUG2NQAALV8X
• ChEMBL ID: CHEMBL269058
• Mol file: 22780-54-7.mol

Synonyms:PIPERIDIN-2-IMINE;22780-54-7;2-iminopiperidine;3,4,5,6-Tetrahydropyridin-2-amine;2-Piperidinimine;Piperidin-(2E)-ylideneamine;Piperidin-(2Z)-ylideneamine;CHEMBL269058;2,3,4,5-tetrahydropyridin-6-amine;NCGC00024898-01;Tocris-0951;D0D0TO;DTXSID40275816;3,4,5,6-tetrahydropyridine amine;BDBM50049255;AKOS002684133;AKOS005199122;SB52268;EN300-77982;Q27453028

Chemical Property of Piperidin-2-imine

Chemical Property:

• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 98.084398327
• Heavy Atom Count: 7
• Complexity: 86.1

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN=C(C1)N

Technology Process of Piperidin-2-imine

There total 2 articles about Piperidin-2-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine-2-thione (13070-01-4) → piperidin-2-one (675-20-7) + 2-iminopiperidine (22780-54-7)

Guidance literature:

With methanol; ammonia; mercury(II) oxide;

Reference yield:

1-benzyl-1H-pyridin-2-ylideneamine (58171-11-2) + acetic acid (64-19-7,77671-22-8) → 2-iminopiperidine (22780-54-7) + 1-benzyl-piperidin-2-one-imine

Guidance literature:

Hydrogenation;

Reference yield: 78.0%

2-amino-3,4,5,6-tetrahydropyridine (22780-54-7) + (3-bromo-2-oxopropyl)((tert-butyldiphenylsilyl)imino)(phenyl)-λ6-sulfanone → ((tert-butyldiphenylsilyl)imino)(phenyl)((5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)methyl)-λ6-sulfanone

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; at 90 ℃; for 15h; Sealed tube; Inert atmosphere;

DOI:10.1039/c7ob00601b

upstream raw materials:

piperidine-2-thione

1-benzyl-1H-pyridin-2-ylideneamine

acetic acid

Downstream raw materials:

3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-6,7,8,9,-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione

3-[3-[4-(4-Fluorobenzoyl)piperidin-1-yl)propyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione

3-[2-[4-(4-fluorobenzoyl)-4-hydroxypiperidin-1-yl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione

3-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-6,7,8,9-tetrahydro-pyrido[1,2-a][1,3,5]triazine-2,4-dione