2-Pyridinamine, N-(2,6-difluorophenyl)-

Base Information

Chemical Name:2-Pyridinamine, N-(2,6-difluorophenyl)-
CAS No.:227805-80-3
Molecular Formula:C11H8F2N2
Molecular Weight:206.195
Hs Code.:
DSSTox Substance ID:DTXSID50477708
Nikkaji Number:J1.881.011E
Wikidata:Q82310565
Mol file:227805-80-3.mol

Synonyms:2-Pyridinamine, N-(2,6-difluorophenyl)-;227805-80-3;SCHEMBL7981869;DTXSID50477708

Suppliers and Price of 2-Pyridinamine, N-(2,6-difluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pyridinamine, N-(2,6-difluorophenyl)-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:206.06555459
Heavy Atom Count:15
Complexity:191

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)NC2=C(C=CC=C2F)F

Technology Process of 2-Pyridinamine, N-(2,6-difluorophenyl)-

There total 1 articles about 2-Pyridinamine, N-(2,6-difluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 109-09-1
2-chloropyridine

: 5509-65-9
2,6-difluoroaniline

: 227805-80-3
2-(2,6-difluorophenylamino)pyridine

Guidance literature:: With potassium tert-butylate; C₆₆H₉₂Cl₃N₃Pd; In n-heptane; at 100 ℃; for 4h;
DOI:10.1002/chem.202103341

Reference yield: 96.0%

: 227805-80-3
2-(2,6-difluorophenylamino)pyridine

: 7550-45-0
titanium tetrachloride

: 1040086-64-3
[(2,6-difluorophenylaminopyridinato)Ti₂Cl₆]

Guidance literature:: With NaH; In diethyl ether; toluene; Ar; ligand treated with NaH excess in Et2O at room temp., soln. filtered, added dropwise to toluene soln. of TiCl4, stirred for 1 h at room temp.; filtered, concd. (vac.), crystd. overnight, elem. anal.;
DOI:10.1016/j.ica.2007.11.028

Reference yield: 89.0%

: 227805-80-3
2-(2,6-difluorophenylamino)pyridine

: 7550-45-0
titanium tetrachloride

: bis(2,6-difluorophenylaminopyridinato) titanium dichloride

Guidance literature:: With NaH; In diethyl ether; toluene; Ar; ligand treated with NaH excess in Et2O at room temp., soln. filtered, added dropwise to toluene soln. of TiCl4, stirred for 1 h at room temp.; filtered, concd. (vac.), crystd. overnight, elem. anal.;
DOI:10.1016/j.ica.2007.11.028