Benzenepropanal, a-propyl-

Base Information

• Chemical Name: Benzenepropanal, a-propyl-
• CAS No.: 22859-83-2
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• Mol file: 22859-83-2.mol

Synonyms:

Chemical Property of Benzenepropanal, a-propyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanal, a-propyl-

There total 5 articles about Benzenepropanal, a-propyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

iodobenzene (591-50-4) + 2-methylvaleraldehyde (123-15-9) → 2-benzylvaleraldehyde (22859-83-2)

Guidance literature:

With palladium diacetate; silver trifluoroacetate; 3-amino propanoic acid; In acetic acid; at 80 ℃; for 24h; Reagent/catalyst; Solvent; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.6b08478

Reference yield: 58.0%

formic acid (64-18-6) + 2-benzyl-1-methoxypentan-2-ol → 2-benzylvaleraldehyde (22859-83-2) + 2-benzylpentyl formate

Guidance literature:

2-benzyl-1-methoxypentan-2-ol; With palladium(II) acetylacetonate; 1,2-bis[di(t-butyl)phosphinomethyl]benzene; In chloroform; at 20 ℃; for 2.5h; Glovebox;

With methanesulfonic acid; In chloroform; at 20 ℃; for 0.5h; Glovebox;

formic acid; In chloroform; at 100 ℃; for 4h; Glovebox; Sealed tube;

DOI:10.1002/chem.202000251

Reference yield: 52.0%

iodobenzene (591-50-4) + C14H20N2O2Pd → 2-benzylvaleraldehyde (22859-83-2)

Guidance literature:

With silver trifluoroacetate; In acetic acid; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.6b08478

upstream raw materials:

4,4,6-trimethyl-2-vinyl-5,6-dihydro-4H-[1,3]oxazine

ethylmagnesium bromide

benzyl bromide

iodobenzene