ETHYL 3-(4-CHLOROPHENYL)-2-CYANOACRYLATE

Base Information

• Chemical Name: ETHYL 3-(4-CHLOROPHENYL)-2-CYANOACRYLATE
• CAS No.: 2286-35-3
• Molecular Formula: C12H10ClNO2
• Molecular Weight: 235.67
• Hs Code.: 2926909090
• Mol file: 2286-35-3.mol

Synonyms:2-propionamido-tetralin;ethyl 4-chlorobenzylidene-cyanoacetate;2-propionic acid;

Chemical Property of ETHYL 3-(4-CHLOROPHENYL)-2-CYANOACRYLATE

Chemical Property:

• Melting Point: 91-92 °C
• Boiling Point: 185-200 °C(Press: 2.5 Torr)
• PSA: 50.09000
• Density: 1.249±0.06 g/cm3(Predicted)
• LogP: 2.81008

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-(4-chlorophenyl)-2-cyanoacrylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-(4-CHLOROPHENYL)-2-CYANOACRYLATE

There total 11 articles about ETHYL 3-(4-CHLOROPHENYL)-2-CYANOACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chlorobenzaldehyde dimethyl acetal (3395-81-1) + ethyl 2-cyanoacetate (105-56-6) → ethyl 3-(4-chlorophenyl)-2-cyanoacrylate (2286-35-3)

Guidance literature:

With MS-SO₃H(at)MS(at)MS-NH₂; In toluene; at 80 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1039/c3ta13185h

Reference yield: 99.0%

4-chlorobenzaldehyde (104-88-1) + ethyl 2-cyanoacetate (105-56-6) → ethyl 3-(4-chlorophenyl)-2-cyanoacrylate (2286-35-3)

Guidance literature:

With N,N-dimethyl-N-hydroxyethylammonium acetate; at 20 ℃; for 0.333333h;

DOI:10.1016/j.cattod.2012.06.006

Reference yield: 83.0%

ethyl 2-cyanoacetate (105-56-6) + para-Chlorobenzyl alcohol (873-76-7) → ethyl 3-(4-chlorophenyl)-2-cyanoacrylate (2286-35-3)

Guidance literature:

With dihydrogen peroxide; In water; acetonitrile; at 80 ℃; for 24h; Catalytic behavior;

DOI:10.1002/cctc.201501365

upstream raw materials:

4-chlorobenzaldehyde

ethyl 2-cyanoacetate

1-(4-{[(4-chlorophenyl)methylene]amino}phenyl)ethanone

ethanol

Downstream raw materials:

3-(4-chlorophenyl)-2-cyanoacrylic acid

4-(4-Chloro-phenyl)-1-cyano-2,2,3,3-tetramethoxy-cyclobutanecarboxylic acid ethyl ester

5-amino-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylene]-2,3-dihydro-3-oxo-7H-thiazolo[3,2-a]pyridine-6,8-dicarboxylic acid 6,8-diethyl ester

ethyl 2-amino-4-(p-chlorophenyl)-4H-pyrano<3,2-h>quinoline-3-carboxylate