Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-2-[4-[[(ethylamino)carbonyl]amino]phenyl]- 5,8-dihydro-3-[[methyl(phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

Base Information

Chemical Name:Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-2-[4-[[(ethylamino)carbonyl]amino]phenyl]- 5,8-dihydro-3-[[methyl(phenylmethyl)amino]methyl]-5-oxo-, ethyl ester
CAS No.:229484-80-4
Molecular Formula:C34H34F2N6O4
Molecular Weight:628.679
Hs Code.:
Mol file:229484-80-4.mol

Imidazo[1,2-a]pyrimidine-6-carboxylic acid,
8-[(2,6-difluorophenyl)methyl]-2-[4-[[(ethylamino)carbonyl]amino]phenyl]-
5,8-dihydro-3-[[methyl(phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

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Chemical Property of Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-2-[4-[[(ethylamino)carbonyl]amino]phenyl]- 5,8-dihydro-3-[[methyl(phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

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Technology Process of Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-2-[4-[[(ethylamino)carbonyl]amino]phenyl]- 5,8-dihydro-3-[[methyl(phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

There total 9 articles about Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 8-[(2,6-difluorophenyl)methyl]-2-[4-[[(ethylamino)carbonyl]amino]phenyl]- 5,8-dihydro-3-[[methyl(phenylmethyl)amino]methyl]-5-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 109-90-0
ethyl isocyanate

: 229484-76-8
2-(4-aminophenyl)-8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

: 229484-80-4
8-(2,6-difluorobenzyl)-5,8-dihydro-2-[4-(ethylaminocarbonylamino)phenyl]-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: With pyridine; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2007.04.065

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 229484-80-4
8-(2,6-difluorobenzyl)-5,8-dihydro-2-[4-(ethylaminocarbonylamino)phenyl]-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / K₂CO₃; KI / dimethylformamide

2: 89 percent / NaNO₃; conc. H₂SO₄

3: NBS; AIBN / CCl₄

4: i-Pr₂NEt / dimethylformamide

5: 95 percent / Fe; conc. aq. HCl / ethanol

6: 65 percent / pyridine

With pyridine; hydrogenchloride; sodium nitrate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00372-4

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 229484-80-4
8-(2,6-difluorobenzyl)-5,8-dihydro-2-[4-(ethylaminocarbonylamino)phenyl]-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 37 percent / K₂CO₃; KI / dimethylformamide

2: 78 percent / Zn; AcOH

3: 85 percent / K₂CO₃; KI / dimethylformamide

4: 89 percent / NaNO₃; conc. H₂SO₄

5: NBS; AIBN / CCl₄

6: i-Pr₂NEt / dimethylformamide

7: 95 percent / Fe; conc. aq. HCl / ethanol

8: 65 percent / pyridine

With pyridine; hydrogenchloride; sodium nitrate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; iron; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00372-4