Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 2-(4-aminophenyl)-8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-[[methyl( phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

Base Information

Chemical Name:Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 2-(4-aminophenyl)-8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-[[methyl( phenylmethyl)amino]methyl]-5-oxo-, ethyl ester
CAS No.:229484-76-8
Molecular Formula:C31H29F2N5O3
Molecular Weight:557.6
Hs Code.:
Mol file:229484-76-8.mol

Imidazo[1,2-a]pyrimidine-6-carboxylic acid,
2-(4-aminophenyl)-8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-[[methyl(
phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

Synonyms:

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Chemical Property of Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 2-(4-aminophenyl)-8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-[[methyl( phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

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Technology Process of Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 2-(4-aminophenyl)-8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-[[methyl( phenylmethyl)amino]methyl]-5-oxo-, ethyl ester

There total 9 articles about Imidazo[1,2-a]pyrimidine-6-carboxylic acid, 2-(4-aminophenyl)-8-[(2,6-difluorophenyl)methyl]-5,8-dihydro-3-[[methyl( phenylmethyl)amino]methyl]-5-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 229484-63-3
8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-2-(4-nitrophenyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

: 229484-76-8
2-(4-aminophenyl)-8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; iron; In ethanol;
DOI:10.1016/S0960-894X(02)00372-4

Reference yield:

: 697-73-4
2,6-difluorobenzyl chloride

: 229484-76-8
2-(4-aminophenyl)-8-(2,6-difluorobenzyl)-5,8-dihydro-3-(N-methyl-N-benzylaminomethyl)-5-oxoimidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / K₂CO₃; KI / dimethylformamide

2: 89 percent / NaNO₃; conc. H₂SO₄

3: NBS; AIBN / CCl₄

4: i-Pr₂NEt / dimethylformamide

5: 95 percent / Fe; conc. aq. HCl / ethanol

With hydrogenchloride; sodium nitrate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; iron; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00372-4