4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one

Base Information

• Chemical Name: 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one
• CAS No.: 16404-66-3
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.193
• Mol file: 16404-66-3.mol

Synonyms:2,4,6-Trimethyl-4-hydroxycyclohexa-2,5-dienone;4-Hydroxy-2,4,6-trimethyl-2,5-cyclohexadien-1-one; 4-Hydroxy-2,4,6-trimethylcyclohexa-2,5-dienone;NSC 301464

Chemical Property of 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one

Chemical Property:

• Vapor Pressure: 0.000751mmHg at 25°C
• Boiling Point: 273.1°C at 760 mmHg
• Flash Point: 114°C
• Density: 1.08g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one

There total 33 articles about 4-hydroxy-2,4,6-trimethylcyclohexa-2,5-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroperoxy-2,4,6-trimethyl-2,5-cyclohexadien-1-one (33919-00-5) → 4-hydroxy-2,4,6-trimethyl-cyclohexa-2,5-dienone (16404-66-3)

Guidance literature:

With triphenylphosphine; In dichloromethane; for 3h; Heating;

DOI:10.1246/bcsj.55.3852

Reference yield: 99.0%

Mesitol (527-60-6) → 4-hydroxy-2,4,6-trimethyl-cyclohexa-2,5-dienone (16404-66-3)

Guidance literature:

With cesium hydroxide; oxygen; triethyl phosphite; In dimethyl sulfoxide; at 25 ℃; for 12h; under 760.051 Torr; Reagent/catalyst; Solvent; Catalytic behavior;

DOI:10.1007/s11426-015-5363-4

Reference yield: 95.0%

2,4,6-trimethylbenzamide (4380-68-1) → 4-hydroxy-2,4,6-trimethyl-cyclohexa-2,5-dienone (16404-66-3)

Guidance literature:

With iodobenzene; oxone; water; In acetonitrile; at 20 ℃;

DOI:10.1021/ol101993q

upstream raw materials:

Mesitol

2,4,6-trimethylaniline

2,6-dimethyl-1,4-benzoquinone

methyllithium

Downstream raw materials:

1-acetoxy-2,3,4,6-tetramethylbenzene

2,4,6-trimethyl-3-hydroxybiphenyl

4-hydroxy-2,4,6-trimethyl-5-phenyl-cyclohex-2-enone

Mesitol