Technology Process of Acetamide,
N-[[(2R,3R,4R,5R)-1-methyl-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy
)methyl]-2-pyrrolidinyl]methyl]-
There total 11 articles about Acetamide,
N-[[(2R,3R,4R,5R)-1-methyl-3,4-bis(phenylmethoxy)-5-[(phenylmethoxy
)methyl]-2-pyrrolidinyl]methyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride;
In
methanol;
Ambient temperature;
DOI:10.1021/jo9902446
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) LiAlH4, 2.) Et3N / 1.) THF, 2.) CH2Cl2
2: 424 mg / Et3N / CH2Cl2 / 2 h / Ambient temperature
3: 65 percent / NaN3 / dimethylformamide / 35 h / 70 °C
4: 59 mg / H2 / 5 percent Pd on C / methanol / 1.5 h / Ambient temperature
5: 83 percent / pyridine
6: 96 percent / TFA / H2O / 2 h / Ambient temperature
7: 71 percent / NaBH3CN / methanol / Ambient temperature
With
lithium aluminium tetrahydride; sodium azide; hydrogen; sodium cyanoborohydride; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo9902446
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 91 percent / PPh3 / tetrahydrofuran; H2O / 48 h / Ambient temperature
2: 91 percent / Et3N / CH2Cl2 / 20 h / Ambient temperature
3: 684.8 mg / Pb(OAc)4 / toluene / 1.5 h / Ambient temperature
4: 97 percent / DIBAL / CH2Cl2; hexane / 0.5 h / 0 °C
5: 424 mg / Et3N / CH2Cl2 / 2 h / Ambient temperature
6: 65 percent / NaN3 / dimethylformamide / 35 h / 70 °C
7: 59 mg / H2 / 5 percent Pd on C / methanol / 1.5 h / Ambient temperature
8: 83 percent / pyridine
9: 96 percent / TFA / H2O / 2 h / Ambient temperature
10: 71 percent / NaBH3CN / methanol / Ambient temperature
With
lead(IV) acetate; sodium azide; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; triphenylphosphine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo9902446
