8-(tert-Butoxy)-8-oxooctanoic acid

Base Information

• Chemical Name: 8-(tert-Butoxy)-8-oxooctanoic acid
• CAS No.: 234081-94-8
• Molecular Formula: C12H22O4
• Molecular Weight: 230.304
• Mol file: 234081-94-8.mol

Synonyms:7-t-butoxycarbonylheptanoic acid;8-tert-butoxy-8-oxooctanoic acid;Octanedioic acid mono-tert-butyl ester;

Chemical Property of 8-(tert-Butoxy)-8-oxooctanoic acid

Chemical Property:

• Boiling Point: 324.8±25.0 °C(Predicted)
• PKA: 4.76±0.10(Predicted)
• PSA: 63.60000
• Density: 1.024±0.06 g/cm3(Predicted)
• LogP: 2.75330
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

8-(tert-Butoxy)-8-oxooctanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(tert-Butoxy)-8-oxooctanoic acid

There total 7 articles about 8-(tert-Butoxy)-8-oxooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

octane-1,8-dioic acid (505-48-6) + tert-butyl alcohol (75-65-0) → suberic acid mono-tert-butyl ester (234081-94-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;

Reference yield: 24.0%

oxonane-2,9-dione (10521-06-9) + tert-butyl alcohol (75-65-0) → suberic acid mono-tert-butyl ester (234081-94-8)

Guidance literature:

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; In toluene; for 24h; Reflux;

DOI:10.3390/molecules26185475

Reference yield:

methanol-water-tetrahydrofuran + tert-butyl 7-(methoxycarbonyl)heptanoate (137299-08-2) → suberic acid mono-tert-butyl ester (234081-94-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide;

upstream raw materials:

octane-1,8-dioic acid

tert-butyl alcohol

tert-butyl 7-(methoxycarbonyl)heptanoate

suberic acid monomethyl ester

Downstream raw materials:

tert-butyl 8-hydroxyoctanoate

7-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-heptanoic acid

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