Tyrosine, N-acetyl-, methyl ester

Base Information

• Chemical Name: Tyrosine, N-acetyl-, methyl ester
• CAS No.: 23525-90-8
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.255
• Hs Code.: 2924299090
• Mol file: 23525-90-8.mol

Synonyms:2-acetylamino-3-(4-hydroxy-phenyl)-propionic acid methyl ester;N-Acetyltyrosinmethylester;N-acetyltyrosine methyl ester;N-ACETYL-DL-TYROSINE METHYL ESTER;methyl N-acetyl-tyrosinate;N-acetyl tyrosine methyl ester;methyl 2-acetamido-3-(4-hydroxyphenyl)propanoate;

Chemical Property of Tyrosine, N-acetyl-, methyl ester

Chemical Property:

• Boiling Point: 457.0±35.0 °C(Predicted)
• PSA: 75.63000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 1.00330

Purity/Quality:

N-ACETYL-DL-TYROSINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tyrosine, N-acetyl-, methyl ester

There total 5 articles about Tyrosine, N-acetyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-acetyl-N-methoxyacetamide (128459-09-6) + L-Tyr-OCH3 (1080-06-4) → L-Tyr-OCH3 (2440-79-1,23525-90-8,65160-71-6)

Guidance literature:

In N,N-dimethyl-formamide; for 3.5h; Ambient temperature;

DOI:10.1016/S0040-4039(00)94382-X

Reference yield: 93.0%

3-(4-acetoxy-phenyl)-2-acetylamino-propionic acid methyl ester → 2-acetylamino-3-(4-hydroxyphenyl)propionic acid methyl ester (23525-90-8)

Guidance literature:

With ammonium acetate; In methanol; at 20 ℃; for 5h;

DOI:10.1016/S0040-4020(02)01635-6

Reference yield: 85.0%

tyrosine methyl ester (1080-06-4,3410-66-0,18869-47-1) + acetyl chloride (75-36-5) → 2-acetylamino-3-(4-hydroxyphenyl)propionic acid methyl ester (23525-90-8)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 1h; Heating / reflux;

upstream raw materials:

tyrosine methyl ester

acetyl chloride

N-acetyl-N-methoxyacetamide

L-Tyr-OCH₃

Downstream raw materials:

N-acetyltyrosine

N-acetyl-L-tyrosine

Ac-D-Tyrosine

methyl (2R)-2-acetamido-3-(4-hydroxyphenyl)propanoate