Ethyl 2-oxotetrahydrofuran-3-carboxylate

Base Information

• Chemical Name: Ethyl 2-oxotetrahydrofuran-3-carboxylate
• CAS No.: 77513-58-7
• Molecular Formula: C7H10 O4
• Molecular Weight: 158.154
• European Community (EC) Number: 278-703-9
• DSSTox Substance ID: DTXSID60918298
• Nikkaji Number: J706.349K
• Mol file: 77513-58-7.mol

Synonyms:ethyl 2-oxotetrahydrofuran-3-carboxylate;77513-58-7;Carbethoxybutyrolactone;ethyl 2-oxooxolane-3-carboxylate;936-13-0;BRN 0130517;Tetrahydro-2-oxo-3-furoic acid ethyl ester;Ethyl tetrahydro-2-oxo-3-furancarboxylate;3-Furoic acid, tetrahydro-2-oxo-, ethyl ester;3-Furancarboxylic acid, tetrahydro-2-oxo-, ethyl ester;5-18-08-00005 (Beilstein Handbook Reference);ethyl (+/-)-tetrahydro-2-oxo-3-furoate;SCHEMBL7370611;DTXSID60918298;CDA51358;MFCD01725680;ethyl2-oxotetrahydrofuran-3-carboxylate;Ethyl (+-)-tetrahydro-2-oxo-3-furoate;DS-15234;LS-70822;D82353;2-Oxotetrahydrofuran-3-carboxylic acid ethyl ester;3-Furancarboxylic acid, tetrahydro-2-oxo-, ethyl ester (9CI)

Chemical Property of Ethyl 2-oxotetrahydrofuran-3-carboxylate

Chemical Property:

• Boiling Point: 140 °C(Press: 10 Torr)
• PKA: 13.15±0.20(Predicted)
• PSA: 63.60000
• Density: 1.1870 g/cm3(Temp: 17 °C)
• LogP: 0.53790
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 158.05790880
• Heavy Atom Count: 11
• Complexity: 175

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-oxotetrahydrofuran-3-carboxylate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1CCOC1=O

Technology Process of Ethyl 2-oxotetrahydrofuran-3-carboxylate

There total 14 articles about Ethyl 2-oxotetrahydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-dimethylaminomethyl-2-oxo-tetrahydro-furan-3-carboxylic acid ethyl ester → ethyl 2-oxotetrahydrofuran-3-carboxylate (77513-58-7,936-13-0)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol901608k

Reference yield: 84.0%

4-butanolide (96-48-0) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-oxotetrahydrofuran-3-carboxylate (77513-58-7,936-13-0)

Guidance literature:

With sodium hydride; at 45 - 50 ℃; for 1.5h;

Reference yield: 46.0%

4-butanolide (96-48-0) + ethyl cyanoformate (623-49-4) → ethyl 2-oxotetrahydrofuran-3-carboxylate (77513-58-7,936-13-0)

Guidance literature:

4-butanolide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 2.16667h;

ethyl cyanoformate; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ja4078864

upstream raw materials:

Ethyl (2-chloroethyl) malonate

oxirane

sodium diethylmalonate

4-butanolide

Downstream raw materials:

7-phenethyl-2-oxa-7-aza-spiro[4.4]nonane-1,6-dione

3-methyl-4-phenyl-2,7-dioxa-3-aza-spiro[4.4]nonane-1,6-dione

3-ethyl-2-oxotetrahydrofuran-3-carboxylic acid ethyl ester

3-benzyltetrahydrofuran-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 77513-58-7 ethyl (±)-tetrahydro-2-oxo-3-furoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send