4',5'-Dimethoxy-2'-methylacetophenone

Base Information

• Chemical Name: 4',5'-Dimethoxy-2'-methylacetophenone
• CAS No.: 24186-66-1
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2914509090
• European Community (EC) Number: 662-090-3
• DSSTox Substance ID: DTXSID00383608
• Nikkaji Number: J3.579.719J
• Wikidata: Q82175395
• Mol file: 24186-66-1.mol

Synonyms:24186-66-1;4',5'-Dimethoxy-2'-methylacetophenone;1-(4,5-dimethoxy-2-methylphenyl)ethan-1-one;1-(4,5-dimethoxy-2-methylphenyl)ethanone;MFCD00156678;Ethanone, 1-(4,5-dimethoxy-2-methylphenyl)-;SCHEMBL11154634;DTXSID00383608;VJQQZPBPWOLATE-UHFFFAOYSA-N;4,5-Dimethoxy-2-methylacetophenone;ZAA18666;AC1226;AKOS009158980;2'-methyl-4',5'-dimethoxyacetophenone;AS-65741;SY023368;CS-0153306;FT-0750332;1-(4,5-Dimethoxy-2-methyl-phenyl)-ethanone;EN300-73214;Ethanone,1-(4,5-dimethoxy-2-methylphenyl)-;J3.579.719J;A918767;Z442347432;4 inverted exclamation mark ,5 inverted exclamation mark -Dimethoxy-2 inverted exclamation mark -methylacetophenone

Chemical Property of 4',5'-Dimethoxy-2'-methylacetophenone

Chemical Property:

• Melting Point: 68 °C
• Boiling Point: 301.4±37.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.048±0.06 g/cm3(Predicted)
• LogP: 2.21480
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

1-(4,5-Dimethoxy-2-methylphenyl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1C(=O)C)OC)OC

Technology Process of 4',5'-Dimethoxy-2'-methylacetophenone

There total 20 articles about 4',5'-Dimethoxy-2'-methylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

O-ethyl S-2-(4-methoxyphenyl)-2-oxoethyl carbonodithioate (93624-01-2) → 2-methyl-4,5-dimethoxybenzaldehyde (24186-66-1)

Guidance literature:

In isopropyl alcohol; for 15h; Irradiation; Inert atmosphere;

DOI:10.1021/jo201385b

Reference yield: 82.0%

1,2-dimethoxy-4-methylbenzene (494-99-5) + acetic anhydride (108-24-7) → 2-methyl-4,5-dimethoxybenzaldehyde (24186-66-1)

Guidance literature:

With lithium perchlorate; at 60 ℃; for 1h;

DOI:10.1021/ol801291k

Reference yield: 71.0%

C11H13N3O2 → 2-methyl-4,5-dimethoxybenzaldehyde (24186-66-1)

Guidance literature:

With trimethylphosphane; In tetrahydrofuran; at 20 - 25 ℃; for 24h; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c9cc01679a

upstream raw materials:

1,2-dimethoxy-4-methylbenzene

acetyl chloride

acetic anhydride

dimethyl sulfate

Downstream raw materials:

(E,E)-di-<2-methyl-4,5-dimethoxybenzylidene>-succinic acid

1,2-dimethoxy-4-methyl-5-nitrobenzene

(4,5-dimethoxy-2-methyl-phenyl)-glyoxylic acid

m-hemipinic acid