(alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid

Base Information

Chemical Name:(alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid
CAS No.:24190-08-7
Molecular Formula:C10H12O3
Molecular Weight:180.203
Hs Code.:
DSSTox Substance ID:DTXSID701270427
Nikkaji Number:J66.153H

Synonyms:SCHEMBL22722985;DTXSID701270427;(alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid;24190-08-7

Suppliers and Price of (alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:180.078644241
Heavy Atom Count:13
Complexity:185

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)(C(=O)O)OC
Isomeric SMILES:C[C@@](C1=CC=CC=C1)(C(=O)O)OC

Technology Process of (alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid

There total 15 articles about (alphaR)-alpha-Methoxy-alpha-methylbenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 91899-79-5
(S)-2-methoxy-2-phenylpropanal

: 24190-08-7
(R)-(-)-2-methoxy-2-phenylpropionic acid

Guidance literature:: With jones reagent; In acetone; at 20 ℃; for 0.166667h;
DOI:10.1055/s-2004-815406

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 24190-08-7
(R)-(-)-2-methoxy-2-phenylpropionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N / tetrahydrofuran / 3 h / 20 °C

2.1: NaOH; Ca(OH)2 / cetyltrimethylammonium chloride / CHCl₃ / 1 h / 20 - 50 °C / ultrasound irradiation

2.2: 135 mg / aq. HCl / methanol / 2 h / 20 °C

3.1: K₂CO₃ / methanol / 0.17 h / 20 °C

4.1: 76 percent / tetrahydrofuran / 10 h / 20 °C

5.1: 95 percent / K₂CO₃ / 10 h / 20 °C

6.1: 95 percent / NaH / dimethylformamide / 10 h / 20 °C

7.1: 75 percent / aq. H₂SO₄ / tetrahydrofuran / 5 h / Heating

8.1: 85 percent / Jones reagent / acetone / 0.17 h / 20 °C

With calcium hydroxide; sodium hydroxide; jones reagent; sulfuric acid; sodium hydride; potassium carbonate; triethylamine; cetyltrimethylammonium chloride; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone; 8.1: Jones oxidation;
DOI:10.1055/s-2004-815406

Reference yield:

: 98857-41-1
(R)-(+)-1-trimethylsiloxyethylbenzene

: 24190-08-7
(R)-(-)-2-methoxy-2-phenylpropionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaOH; Ca(OH)2 / cetyltrimethylammonium chloride / CHCl₃ / 1 h / 20 - 50 °C / ultrasound irradiation

1.2: 135 mg / aq. HCl / methanol / 2 h / 20 °C

2.1: K₂CO₃ / methanol / 0.17 h / 20 °C

3.1: 76 percent / tetrahydrofuran / 10 h / 20 °C

4.1: 95 percent / K₂CO₃ / 10 h / 20 °C

5.1: 95 percent / NaH / dimethylformamide / 10 h / 20 °C

6.1: 75 percent / aq. H₂SO₄ / tetrahydrofuran / 5 h / Heating

7.1: 85 percent / Jones reagent / acetone / 0.17 h / 20 °C

With calcium hydroxide; sodium hydroxide; jones reagent; sulfuric acid; sodium hydride; potassium carbonate; cetyltrimethylammonium chloride; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone; 7.1: Jones oxidation;
DOI:10.1055/s-2004-815406