Dibenzyl pyridine-2,5-dicarboxylate

Base Information

• Chemical Name: Dibenzyl pyridine-2,5-dicarboxylate
• CAS No.: 24202-70-8
• Molecular Formula: C21H17NO4
• Molecular Weight: 347.37
• DSSTox Substance ID: DTXSID70557470
• Wikidata: Q82439394
• Mol file: 24202-70-8.mol

Synonyms:Dibenzyl pyridine-2,5-dicarboxylate;24202-70-8;SCHEMBL4984363;DTXSID70557470;AVCHXFWJIVVCEC-UHFFFAOYSA-N;pyridine-2,5-dicarboxylic acid dibenzyl ester

Chemical Property of Dibenzyl pyridine-2,5-dicarboxylate

Chemical Property:

• PSA: 65.49000
• LogP: 3.79560
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 347.11575802
• Heavy Atom Count: 26
• Complexity: 455

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)C2=CN=C(C=C2)C(=O)OCC3=CC=CC=C3

Technology Process of Dibenzyl pyridine-2,5-dicarboxylate

There total 2 articles about Dibenzyl pyridine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-2,5-dicarboxylic acid dichloride (5620-35-9) + benzyl alcohol (100-51-6,185532-71-2) → pyridine-2,5-dicarboxylic acid dibenzyl ester (24202-70-8)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

→ pyridine-2,5-dicarboxylic acid dibenzyl ester (24202-70-8)

Guidance literature:

2,5-Pyridindicarbonsaeure, entspr. Alkohol, H⁺;

Reference yield: 74.0%

pyridine-2,5-dicarboxylic acid dibenzyl ester (24202-70-8) → 5-((benzyloxy)carbonyl)picolinic acid (24202-71-9)

Guidance literature:

pyridine-2,5-dicarboxylic acid dibenzyl ester; With methanol; copper(II) sulfate; for 1h; Heating / reflux;

With hydrogen sulfide; In 1,4-dioxane; at 20 ℃;

upstream raw materials:

pyridine-2,5-dicarboxylic acid dichloride

benzyl alcohol

Downstream raw materials:

5-((benzyloxy)carbonyl)picolinic acid