3,5-Dimethylisothiazole

Base Information

• Chemical Name: 3,5-Dimethylisothiazole
• CAS No.: 24260-24-0
• Molecular Formula: C5H7NS
• Molecular Weight: 113.18100
• Hs Code.: 2934999090
• Mol file: 24260-24-0.mol

Synonyms:3,5-dimethylisothiazole;Isothiazole,3,5-dimethyl;3,5 Dimethyl-isothiazol;

Chemical Property of 3,5-Dimethylisothiazole

Chemical Property:

• PSA: 41.13000
• LogP: 1.75990

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dimethylisothiazole

There total 4 articles about 3,5-Dimethylisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-dimethyl-4-isothiazolylmagnesium iodide (113234-28-9) → 3,5-dimethylisothiazole (24260-24-0)

Guidance literature:

With ethyl bromide; In benzene; for 8h; Heating;

Reference yield: 60.0%

pent-3-yn-2-one (7299-55-0) → 3,5-dimethylisothiazole (24260-24-0)

Guidance literature:

pent-3-yn-2-one; With hydroxylamine-O-sulfonic acid; In water; at 0 ℃; for 0.5h;

With sodium hydrogen sulfide; sodium hydrogencarbonate; In water; at 20 ℃; for 12h;

Reference yield:

5-iodo-3-methylisothiazole (20067-15-6) + dihydroxy-methyl-borane (13061-96-6) → 3,5-dimethylisothiazole (24260-24-0)

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); caesium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

3,5-dimethyl-4-isothiazolylmagnesium iodide

pent-3-yn-2-one

5-iodo-3-methylisothiazole

dihydroxy-methyl-borane

Downstream raw materials:

3-Methyl-5-phenethyl-isothiazole

3,5-Diphenethyl-isothiazole

Refernces

• 1、 -. "PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF". Paragraph 0291; 0292; 0293. . Retrieved 2018/10/24.
• 2、 Alberola, Angel,Alonso, Felisa,Cuadrado, Purificacion,Sanudo, Maria Carmen. "3,5-DIMETHYL-4-ISOTHIAZOLYLMAGNESIUM IODIDE AND ITS REACTIONS WITH SOME ELECTROPHILIC REAGENTS". . p. 1207 - 1216. Retrieved 2007/10/02.