2,5-Diisopropylpyrazine

Base Information

• Chemical Name: 2,5-Diisopropylpyrazine
• CAS No.: 24294-83-5
• Molecular Formula: C10H16N2
• Molecular Weight: 164.24700
• Hs Code.: 2933990090
• Mol file: 24294-83-5.mol

Synonyms:2,5-Diisopropyl-pyrazin;2,5-Diisopropylpyrazin;2,5-Di-i-propylpyrazin;2,5-di-iso-propylpyrazine;2,5-diisopropylpyrazine;2,5-diisopropyl-pyrazine;

Chemical Property of 2,5-Diisopropylpyrazine

Chemical Property:

• PSA: 25.78000
• LogP: 2.72340

Purity/Quality:

99% ^*data from raw suppliers

2,5-Diisopropylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-Diisopropylpyrazine

There total 22 articles about 2,5-Diisopropylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

triethyl borane (97-94-9) + 3-chloro-2,5-bis(1-methylethyl)pyrazine (74152-17-3) → 2,5-bis(1-methylethyl)pyrazine (24294-83-5) + 2-ethyl-3,6-diisopropylpyrazine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.3987/R-1987-09-2449

Reference yield: 86.0%

valinol (16369-05-4,473-75-6) → 2,5-bis(1-methylethyl)pyrazine (24294-83-5)

Guidance literature:

With C₃₉H₃₁BMnNO₂P₂; potassium hydride; In toluene; at 150 ℃; for 24h;

DOI:10.1021/acscatal.8b02208

Reference yield: 76.0%

isopropyl bromide (75-26-3) + 2-(1-methylethyl)pyrazine (29460-90-0) → 2,5-bis(1-methylethyl)pyrazine (24294-83-5) + 2,6-diisopropylpyrazine (222048-85-3) + 2,3-bis(1-methylethyl)pyrazine (64931-21-1)

Guidance literature:

isopropyl bromide; With magnesium; In tetrahydrofuran; at 0 ℃; for 1h;

2-(1-methylethyl)pyrazine; In tetrahydrofuran; at 0 ℃; for 0.25h; Further stages.;

DOI:10.1016/j.tet.2004.03.005

upstream raw materials:

1-amino-3-methyl-butan-2-one

triethyl borane

3-chloro-2,5-bis(1-methylethyl)pyrazine

diethylzinc

Downstream raw materials:

2,5-diisopropylpiperazine

(+/-)-cis-1,4-dibenzyl-2,5-diisopropylpiperazine

trans-1,4-dibenzyl-2,5-diisopropylpiperazine