1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone

Base Information

Chemical Name:1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone
CAS No.:243640-37-1
Molecular Formula:C22H26FNO4
Molecular Weight:387.451
Hs Code.:
European Community (EC) Number:607-364-5
DSSTox Substance ID:DTXSID801130060
Mol file:243640-37-1.mol

Synonyms:SCHEMBL6024823;SCHEMBL13701291;DTXSID801130060;1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone;243640-37-1

Suppliers and Price of 1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:387.18458647
Heavy Atom Count:28
Complexity:489

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC(=C1OC)C(C2CCN(CC2)C(=O)CC3=CC=C(C=C3)F)O

Technology Process of 1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone

There total 3 articles about 1-[4-[(2,3-Dimethoxyphenyl)hydroxymethyl]-1-piperidinyl]-2-(4-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 140235-25-2
(+/-)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol

: 459-04-1
4-Fluorophenylacetyl chloride

: 243640-37-1
4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophen-1-oxo-ethyl)piperidine

Guidance literature:: With sodium hydroxide; In water; toluene; at 20 - 25 ℃; for 2.3h; Product distribution / selectivity;

Reference yield: 70.0%

: 243640-29-1
4-[1-oxo-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophen-1-oxo-ethyl)piperidine

: 243640-37-1
4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophen-1-oxo-ethyl)piperidine

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; In ethanol; water; at 20 ℃; Product distribution / selectivity;

Reference yield:

: (1-benzyl-piperidin-4-yl)-(2,3-dimethoxy-phenyl)-methanol

: 243640-37-1
4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophen-1-oxo-ethyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / ammonium formate / Pd/C / methanol / 0.75 h / Heating

2: 79 percent / tetrahydrofuran

With ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1002/ejoc.200200586