4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Base Information

Chemical Name:4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol
CAS No.:246245-20-5
Molecular Formula:C8H7F3O2
Molecular Weight:192.138
Hs Code.:
DSSTox Substance ID:DTXSID80461211
Nikkaji Number:J1.218.542A
Mol file:246245-20-5.mol

Synonyms:4-(2,2,2-trifluoro-1-hydroxyethyl)phenol;246245-20-5;4-(1-hydroxy-2,2,2-trifluoroethyl)phenol;SCHEMBL2175953;DTXSID80461211;AKOS010909506;SB85150;CS-0268371;4-(2,2,2-Trifluoro-1-hydroxy-ethyl)-phenol;EN300-1931419;J-513250

Suppliers and Price of 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

JR MediChem
Benzenemethanol,4-hydroxy-a-(trifluoromethyl)- 96%
25g
$ 4980.00

JR MediChem
Benzenemethanol,4-hydroxy-a-(trifluoromethyl)- 96%
1g
$ 398.00

JR MediChem
Benzenemethanol,4-hydroxy-a-(trifluoromethyl)- 96%
5g
$ 1280.00

Crysdot
4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol 95+%
1g
$ 510.00

Chemenu
4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol 95%
1g
$ 482.00

American Custom Chemicals Corporation
4-(2,2,2-TRIFLUORO-1-HYDROXYETHYL)PHENOL 95.00%
5MG
$ 502.48

Alichem
4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol
5g
$ 2010.00

Total 9 raw suppliers

Chemical Property of 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Chemical Property:

Boiling Point:278.3±40.0 °C(Predicted)
PKA:9.52±0.26(Predicted)
PSA：40.46000
Density:1.419±0.06 g/cm3(Predicted)
LogP:1.98790
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:192.03981395
Heavy Atom Count:13
Complexity:161

Purity/Quality:

≥95% ^*data from raw suppliers

Benzenemethanol,4-hydroxy-a-(trifluoromethyl)- 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C(F)(F)F)O)O

Technology Process of 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

There total 16 articles about 4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 246245-20-5
2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl alcohol

Guidance literature:: (trifluoromethyl)trimethylsilane; 4-hydroxy-benzaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With water; In N,N-dimethyl-formamide; for 4h; Acidic conditions;
DOI:10.1016/j.tetlet.2013.06.045

Reference yield: 92.0%

: 403648-66-8
(±)-trimethyl-2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxysilane

: 246245-20-5
2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl alcohol

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 15h;
DOI:10.1016/S0022-1139(01)00447-X

Reference yield: 72.0%

: 1-(4-(allyloxy)phenyl)-2,2,2-trifluoroethan-1-ol

: 246245-20-5
2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl alcohol

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 50 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2021.132574