2-(4-Chlorophenyl)quinoline

Base Information

• Chemical Name: 2-(4-Chlorophenyl)quinoline
• CAS No.: 24698-70-2
• Molecular Formula: C15H10ClN
• Molecular Weight: 239.704
• DSSTox Substance ID: DTXSID201309988
• Nikkaji Number: J1.101.233G
• Mol file: 24698-70-2.mol

Synonyms:2-(4-chlorophenyl)quinoline;24698-70-2;2-(4-Chloro)phenylquinoline;SCHEMBL708675;DTXSID201309988

Chemical Property of 2-(4-Chlorophenyl)quinoline

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 239.0501770
• Heavy Atom Count: 17
• Complexity: 247

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)Cl

Technology Process of 2-(4-Chlorophenyl)quinoline

There total 59 articles about 2-(4-Chlorophenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(E)-3-(2-aminophenyl)-1-(4-chlorophenyl)prop-2-en-1-one (1204482-06-3) → 2-(4-chlorophenyl)quinoline (24698-70-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In 1,2-dichloro-ethane; at 80 ℃; for 14h;

DOI:10.1021/acs.joc.8b00552

Reference yield: 96.0%

2-Aminobenzyl alcohol (5344-90-1) + para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)quinoline (24698-70-2)

Guidance literature:

With C₂₂H₂₄ClN₃ORu; potassium hydroxide; In toluene; at 80 ℃; for 5h; Catalytic behavior; Green chemistry;

DOI:10.1002/aoc.4582

Reference yield: 93.0%

2-Chloroquinoline (612-62-4) + 4-Chlorophenylboronic acid (1679-18-1) → 2-(4-chlorophenyl)quinoline (24698-70-2)

Guidance literature:

With [Pd(3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide)(PPh₃)Cl₂]; potassium carbonate; triphenylphosphine; In water; at 100 ℃; for 18h;

DOI:10.1002/ejoc.201701241

upstream raw materials:

2-(4-chlorophenyl)quinoline-4-carboxylic acid

3-(2-aminophenyl)-1-(4-chlorophenyl)prop-2-yn-1-one

(E)-1-(4-chlorophenyl)-3-(2-nitrophenyl)-2-propen-1-one

2-Aminobenzyl alcohol

Downstream raw materials:

4-chloro-2-(4-chlorophenyl)quinoline-1,3(2H)-dicarbaldehyde

C₂₂H₁₄Cl₂N₂O₃

(?)-(S)-2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinoline