(2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile

Base Information

Chemical Name:(2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile
CAS No.:247016-69-9
Molecular Formula:C15H18N6O
Molecular Weight:371.26500
Hs Code.:
UNII:HCX5M1YIOM
DSSTox Substance ID:DTXSID70624696
Nikkaji Number:J1.243.445F
Wikidata:Q76411441
Pharos Ligand ID:KCVD3BV9VSH2
ChEMBL ID:CHEMBL77538
Mol file:247016-69-9.mol

Synonyms:1-(((2-((5-cyanopyridin-2-yl)amino)ethyl)amino)acetyl)-2-cyano-(S)-pyrrolidine;NVP-DPP728

Suppliers and Price of (2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
NVP DPP 728 dihydrochloride
10mg
$ 480.00

Usbiological
NVP DPP 728 Dihydrochloride
1mg
$ 396.00

DC Chemicals
NVPDPP728dihydrochloride >98%
1 g
$ 2500.00

Crysdot
NVP-728 97%
100mg
$ 750.00

ApexBio Technology
NVPDPP728dihydrochloride
10mg
$ 193.00

ApexBio Technology
NVPDPP728dihydrochloride
10mM (in 1mL DMSO)
$ 150.00

ApexBio Technology
NVPDPP728dihydrochloride
50mg
$ 819.00

American Custom Chemicals Corporation
NVP-728 95.00%
5MG
$ 502.45

Total 8 raw suppliers

Chemical Property of (2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile

Chemical Property:

Melting Point:167 °C (approx)
Boiling Point:612.1±55.0 °C(Predicted)
PKA:7.47±0.20(Predicted)
PSA：104.84000
Density:0.1 g/cm3
LogP:2.47516
Storage Temp.:Desiccate at RT
Solubility.:≥17.75 mg/mL in DMSO with gentle warming; ≥81 mg/mL in EtOH; ≥82 mg/mL in H2O
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:298.15420922
Heavy Atom Count:22
Complexity:475

Purity/Quality:

99% ^*data from raw suppliers

NVP DPP 728 dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N
Isomeric SMILES:C1C[C@H](N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N
Uses NVP DPP 728 Dihydrochloride is a new potent DPP-IV inhibitor class with excellent oral bioavailability and potent antihyperglycemic activity.

Technology Process of (2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile

There total 9 articles about (2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: N-[2-(5-cyano-pyridin-2-ylamino)-ethyl]-N-[2-(2-cyano-pyrrolidin-1-yl)-2-oxo-ethyl]-2,2,2-trifluoro-acetamide

: 247016-69-9
(S)-1-{2-[(5-cyanopyridin-2-yl)amino]ethyl-aminoacetyl}-2-cyano-pyrrolidine

Guidance literature:: With ammonium hydroxide; In dichloromethane; for 3h;
DOI:10.1016/S0040-4020(02)00536-7

Reference yield: 75.0%

: 6-{3-[2-((2S)-cyanopyrrolidin-1-yl)-2-oxoethyl]imidazolidin-1-yl}nicotinonitrile

: 247016-69-9
(S)-1-{2-[(5-cyanopyridin-2-yl)amino]ethyl-aminoacetyl}-2-cyano-pyrrolidine

Guidance literature:: With 3-(4-(hydrazinosulfonyl)phenylpropionyl AM resin; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)00536-7