202460-48-8

Basic information

• Product Name: 6-[(2-AMINOETHYL)AMINO]NICOTINONITRILE
• Synonyms: 6-[(2-AMINOETHYL)AMINO]NICOTINONITRILE
• CAS NO: 202460-48-8
• Molecular Formula: C₈H₁₀N₄
• Molecular Weight: 162.1918
• Mol File: 202460-48-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-[(2-AMINOETHYL)AMINO]NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(2-AMINOETHYL)AMINO]NICOTINONITRILE(202460-48-8)
• EPA Substance Registry System: 6-[(2-AMINOETHYL)AMINO]NICOTINONITRILE(202460-48-8)

Safety Data

• Hazardous Substances Data: 202460-48-8(Hazardous Substances Data)

Upstream product

• 33252-28-7 6-chloronicotinonitrile 
• 107-15-3 ethylenediamine 

Downstream Products

• 252943-80-9 N-[2-(5-cyanopyridin-2-ylamino)ethyl]guanidine 
• 252938-31-1 6-{2-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino}nicotinonitrile 
• 1101322-32-0 6-[(2-{[6-(2,4-Dichlorophenyl)imidazo[1,2-a]pyrazin-8-yl]amino}ethyl)amino]nicotinonitrile 
• 1062195-16-7 6-{[2-({2-(Morpholin-4-ylmethyl)-7-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-c]pyrimidin-5-yl}amino)ethyl]amino}pyridine-3-carbonitrile 
• 1062195-18-9 6-[(2-{[7-(2,4-Dichlorophenyl)-2-(morpholin-4-ylmethyl)[1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-amino}ethyl)amino]pyridine-3-carbonitrile 
• 1062195-21-4 ethyl 5-({2-[(5-cyanopyridin-2-yl)amino]ethyl}amino)-7-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate 
• 761414-79-3 KR-62436 
• 247016-69-9 (S)-1-{2-[(5-cyanopyridin-2-yl)amino]ethyl-aminoacetyl}-2-cyano-pyrrolidine 
• 544677-76-1 6-{2-[2-(2-Chloro-phenyl)-pyrido[3,2-d]pyrimidin-4-ylamino]-ethylamino}-nicotinonitrile 
• 544677-71-6 6-{2-[7-Benzyl-2-(2-trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidin-4-ylamino]-ethylamino}-nicotinonitrile 
• 544676-63-3 6-{2-[2-(2,4-Dichloro-phenyl)-quinazolin-4-ylamino]-ethylamino}-nicotinonitrile 
• 544677-63-6 6-{2-[2-(2-Trifluoromethyl-phenyl)-5,6,7,8-tetrahydro-quinazolin-4-ylamino]-ethylamino}-nicotinonitrile 

Relevant articles and documents

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3

In an effort to identify new antidiabetic agents, we have discovered a novel family of (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine analogues which are inhibitors of human glycogen synthase kinase 3 (GSK3). We developed efficient synthetic routes to explore a wide variety of substitution patterns and convergently access a diverse array of analogues. Compound 1 (CHIR-911, CT-99021, or CHIR-73911) emerged from an exploration of heterocycles at the C-5 position, phenyl groups at C-4, and a variety of differently substituted linker and aminopyridine moieties attached at the C-2 position. These compounds exhibited GSK3 IC50s in the low nanomolar range and excellent selectivity. They activate glycogen synthase in insulin receptor-expressing CHO-IR cells and primary rat hepatocytes. Evaluation of lead compounds 1 and 2 (CHIR-611 or CT-98014) in rodent models of type 2 diabetes revealed that single oral doses lowered hyperglycemia within 60 min, enhanced insulin-stimulated glucose transport, and improved glucose disposal without increasing insulin levels.

Pyrazole Compound

The present invention provides a pyrazole compound represented by the formula (I): wherein ring A0 is a pyrazole ring optionally further having 1 or 2 substituents; Ra is a substituted carbamoyl group; and Rb is an optionally substituted acylamino group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of GSK-3β related pathology or disease, and a GSK-3β inhibitor including same.

GSK-3 inhibitors

This invention relates to methods of treating or preventing bone loss by administering to a human or animal subject pyrimidine and pyridine derivatives that inhibit the activity of glycogen synthase kinase 3 (GSK3), to pharmaceutical compositions containi