1-Methyl-3,4-diphenyl-1H-pyrrole

Base Information

• Chemical Name: 1-Methyl-3,4-diphenyl-1H-pyrrole
• CAS No.: 24963-10-8
• Molecular Formula: C17H15N
• Molecular Weight: 233.313
• DSSTox Substance ID: DTXSID10492639
• Wikidata: Q82338728
• Mol file: 24963-10-8.mol

Synonyms:1-Methyl-3,4-diphenyl-1H-pyrrole;24963-10-8;DTXSID10492639

Chemical Property of 1-Methyl-3,4-diphenyl-1H-pyrrole

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 233.120449483
• Heavy Atom Count: 18
• Complexity: 224

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C=C(C(=C1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Methyl-3,4-diphenyl-1H-pyrrole

There total 9 articles about 1-Methyl-3,4-diphenyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

sarcosine (107-97-1,25951-24-0) + 3-Brom-2,3-diphenylpropenal (53390-75-3) → 1-methyl-3,4-diphenyl-1H-pyrrole (24963-10-8) + 5-bromo-2,3-dihydro-2-methyl-4-phenyl-1H-2-benzazepine (1608154-86-4)

Guidance literature:

In toluene; for 16h; Molecular sieve; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2014.03.078

Reference yield: 62.0%

trimethylamine-N-oxide (1184-78-7) + diphenyl acetylene (501-65-5) → 1-methyl-3,4-diphenyl-1H-pyrrole (24963-10-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; for 3h;

Reference yield: 54.0%

phenylacetaldehyde (122-78-1) + methylamine (74-89-5) → 1-methyl-3,4-diphenyl-1H-pyrrole (24963-10-8)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In acetonitrile; at 80 ℃; for 2h; Inert atmosphere; Electrochemical reaction;

DOI:10.1039/c9gc02118c

upstream raw materials:

N-(3-Benzyl-2-methyl-4-phenyl-isoxazolidin-5-yl)-N-methyl-hydroxylamine

2,3-diphenylbutane-1,4-diylidenebis(methylamine N-oxide)

trimethylamine-N-oxide

diphenyl acetylene