3-Hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

Base Information

Chemical Name:3-Hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone
CAS No.:249764-70-3
Molecular Formula:C17H17NO2
Molecular Weight:267.327
Hs Code.:
DSSTox Substance ID:DTXSID30451001
Nikkaji Number:J1.325.897J
Mol file:249764-70-3.mol

Synonyms:3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone;249764-70-3;SCHEMBL3038205;DTXSID30451001;KJAMARCGRNWFNO-UHFFFAOYSA-N;2-(1-Phenyl-1-methylethyl)-3-hydroxyisoindoline-1-one

Suppliers and Price of 3-Hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:267.125928785
Heavy Atom Count:20
Complexity:373

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C1=CC=CC=C1)N2C(C3=CC=CC=C3C2=O)O

Technology Process of 3-Hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

There total 7 articles about 3-Hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 82573-53-3
N-(1-methyl-1-phenylethyl)benzamide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 249764-70-3
3-hydroxy-2-(1-methyl-1-phenylethyl)-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: N-(1-methyl-1-phenylethyl)benzamide; With sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 0 ℃; for 1h; Further stages.;
DOI:10.1055/s-2006-951495

Reference yield:

: 32366-26-0
cumyl azide

: 249764-70-3
3-hydroxy-2-(1-methyl-1-phenylethyl)-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / LiAlH₄ / diethyl ether / 18 h / 0 - 20 °C

2.1: s-BuLi; TMEDA / tetrahydrofuran / 2 h / -78 °C

2.2: 93 percent / tetrahydrofuran / cooling

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol990846b

Reference yield:

: 617-94-7
1-methyl-1-phenylethyl alcohol

: 249764-70-3
3-hydroxy-2-(1-methyl-1-phenylethyl)-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / LiAlH₄ / diethyl ether / 18 h / 0 - 20 °C

2.1: s-BuLi; TMEDA / tetrahydrofuran / 2 h / -78 °C

2.2: 93 percent / tetrahydrofuran / cooling

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol990846b