N-tert-butyl-4-hydroxybenzamide

Base Information

• Chemical Name: N-tert-butyl-4-hydroxybenzamide
• CAS No.: 250656-24-7
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Hs Code.: 2924297099
• Mol file: 250656-24-7.mol

Synonyms:

Chemical Property of N-tert-butyl-4-hydroxybenzamide

Chemical Property:

• Boiling Point: 366.8±25.0 °C(Predicted)
• PKA: 8.54±0.15(Predicted)
• PSA: 49.33000
• Density: 1.086±0.06 g/cm3(Predicted)
• LogP: 2.31140

Purity/Quality:

99% ^*data from raw suppliers

N-(tert-Butyl)-4-hydroxybenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-tert-butyl-4-hydroxybenzamide

There total 6 articles about N-tert-butyl-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic acid tert-butyl ester (540-88-5) + 4-cyanophenol (767-00-0) → N-(tert-butyl)-4-hydroxybenzamide (250656-24-7)

Guidance literature:

With toluene-4-sulfonic acid; at 80 ℃; for 3.08333h; Reagent/catalyst; Temperature; Green chemistry;

DOI:10.1080/00304948.2016.1194126

Reference yield: 85.8%

4-cyanophenol (767-00-0) + tert-butyl alcohol (75-65-0) → N-(tert-butyl)-4-hydroxybenzamide (250656-24-7)

Guidance literature:

4-cyanophenol; tert-butyl alcohol; With acetic acid; at 15 - 20 ℃; for 0.5h;

With sulfuric acid; at 18 - 40 ℃; for 0.00366667h;

Reference yield: 78.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + p-Iodophenol (540-38-5) → N-(tert-butyl)-4-hydroxybenzamide (250656-24-7)

Guidance literature:

p-Iodophenol; With water; cesium fluoride; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

tert-butylisonitrile; In dimethyl sulfoxide; at 90 ℃; for 9h;

DOI:10.1055/s-0033-1340733

upstream raw materials:

N-(4-hydroxybenzilidene)-tert-butylamine

4-cyanophenol

tert-butyl alcohol

acetic acid tert-butyl ester

Refernces

• 1、 -. "Transition Metal-catalyzed Protocarboxylation of alpha-Halo-acrylic Acid Derivatives". Paragraph 0339-0341. . Retrieved 2018/09/23.
• 2、 Nasr-Esfahani, Masoud,Montazerozohori, Morteza,Karami, Zeinab. "Efficient and Green Ritter Reaction for the Synthesis of N-(t-Butyl)- and N-Benzylamides from t-Butyl and Benzyl Acetates". . p. 321 - 327. Retrieved 2016/08/02.