4-(4-Nitrophenyl)-2-phenyl-1,3-thiazole

Base Information

• Chemical Name: 4-(4-Nitrophenyl)-2-phenyl-1,3-thiazole
• CAS No.: 2521-25-7
• Molecular Formula: C15H10N2O2S
• Molecular Weight: 282.323
• DSSTox Substance ID: DTXSID201296315
• Nikkaji Number: J2.642.079B
• Mol file: 2521-25-7.mol

Synonyms:2521-25-7;4-(4-nitrophenyl)-2-phenyl-1,3-thiazole;Oprea1_850078;SCHEMBL14551142;DTXSID201296315;2-Phenyl-4-(4-nitrophenyl)thiazole;4-(4-Nitrophenyl)-2-phenylthiazole;STL323975;AKOS000989906

Chemical Property of 4-(4-Nitrophenyl)-2-phenyl-1,3-thiazole

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 282.04629874
• Heavy Atom Count: 20
• Complexity: 333

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC(=CS2)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 4-(4-Nitrophenyl)-2-phenyl-1,3-thiazole

There total 11 articles about 4-(4-Nitrophenyl)-2-phenyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Nitrophenacyl bromide (99-81-0) + benzenecarbothioamide (2227-79-4) → 4-(4-nitrophenyl)-2-phenylthiazole (2521-25-7)

Guidance literature:

at 20 ℃; for 0.0833333h; grinding; neat (no solvent);

DOI:10.3184/030823409X401844

Reference yield: 78.0%

2-phenyl-4-(tributylstannyl)thiazole + para-nitrophenyl bromide (586-78-7) → 4-(4-nitrophenyl)-2-phenylthiazole (2521-25-7)

Guidance literature:

With cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; Heating;

DOI:10.1055/s-2007-990972

Reference yield: 75.0%

2-hydroxy-1-(4-nitrophenyl)ethanone (64611-67-2) + benzenecarbothioamide (2227-79-4) → 4-(4-nitrophenyl)-2-phenylthiazole (2521-25-7)

Guidance literature:

2-hydroxy-1-(4-nitrophenyl)ethanone; With triethylamine; In dichloromethane; for 24h; Heating;

benzenecarbothioamide; With potassium carbonate; In acetonitrile; for 10h; Further stages.; Heating;

DOI:10.1080/00397910802136672

upstream raw materials:

2,4-diphenylthiazole

benzenecarbothioamide

(4-nitrophenyl)ethanone

para-nitrophenyl bromide

Downstream raw materials:

4-(2-phenyl-thiazol-4-yl)-aniline

1,3-bis-[4-(2-phenyl-thiazol-4-yl)-phenyl]-thiourea

C₁₅H₉FN₂O₂S