2-Oxazolidinone, 3-[3,5-difluoro-4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]phenyl]- 5-(hydroxymethyl)-, (5R)-

Base Information

• Chemical Name: 2-Oxazolidinone, 3-[3,5-difluoro-4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]phenyl]- 5-(hydroxymethyl)-, (5R)-
• CAS No.: 252328-82-8
• Molecular Formula: C22H22F2N2O3
• Molecular Weight: 400.425
• Mol file: 252328-82-8.mol

Synonyms:

Chemical Property of 2-Oxazolidinone, 3-[3,5-difluoro-4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]phenyl]- 5-(hydroxymethyl)-, (5R)-

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SDS file from LookChem

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Technology Process of 2-Oxazolidinone, 3-[3,5-difluoro-4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]phenyl]- 5-(hydroxymethyl)-, (5R)-

There total 1 articles about 2-Oxazolidinone, 3-[3,5-difluoro-4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]phenyl]- 5-(hydroxymethyl)-, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-benzyloxycarbonyl-3,5-difluoro-4-(1-benzyl-1,2,5,6-tetrahydropyrid-4-yl)aniline (252328-81-7) + (R)-glycidyl butyrate (60456-26-0) → MMV687729 (252328-82-8)

Guidance literature:

With ammonium chloride; In tetrahydrofuran; methanol;

Reference yield: 100.0%

isoxazol-3-ol (5777-20-8,127925-01-3) + MMV687729 (252328-82-8) → 5(R)-(3-oxo-isoxazol-2-ylmethyl)-3-(4-(1-benzyl-1,2,5,6-tetrahydropyrid-4-yl)-3,5-difluorophenyl)oxazolidin-2-one

Guidance literature:

Reference yield: 86.0%

methyl tert-butylether + 2-Methylpentane (107-83-5) + isoxazol-3-ol (5777-20-8,127925-01-3) + diisopropyl (E)-azodicarboxylate (2446-83-5) + MMV687729 (252328-82-8) → MMV687813 (252328-83-9)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran;

upstream raw materials:

N-benzyloxycarbonyl-3,5-difluoro-4-(1-benzyl-1,2,5,6-tetrahydropyrid-4-yl)aniline

(R)-glycidyl butyrate

Downstream raw materials:

(R)-3-[3,5-Difluoro-4-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-5-([1,2,5]thiadiazol-3-yloxymethyl)-oxazolidin-2-one

acetic acid 2-(4-{2,6-difluoro-4-[2-oxo-5-([1,2,5]thiadiazol-3-yloxymethyl)-oxazolidin-3-yl]-phenyl}-3,6-dihydro-2H-pyridin-1-yl)-2-oxo-ethyl ester

3-(4-(1-benzyl-1,2,5,6-tetrahydropyrid-4-yl)-3,5-difluorophenyl)-5(R)-acetoxymethyloxazolidin-2-one

3-(4-(1-benzyl-1,2,5,6-tetrahydropyrid-4-yl-3,5-difluorophenyl)-5(R)-N-(t-butoxycarbonyl)-1,2,5-thiadiazol-3-ylaminomethyl)oxazolidin-2-one

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