5-Hydrazinyl-4-methyl-3-phenylisoxazole

Base Information

• Chemical Name: 5-Hydrazinyl-4-methyl-3-phenylisoxazole
• CAS No.: 25388-07-2
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.217
• DSSTox Substance ID: DTXSID70571939
• Nikkaji Number: J938.860E
• Wikidata: Q82460136
• Mol file: 25388-07-2.mol

Synonyms:5-hydrazinyl-4-methyl-3-phenylisoxazole;25388-07-2;DTXSID70571939;5-Hydrazinyl-4-methyl-3-phenyl-1,2-oxazole

Chemical Property of 5-Hydrazinyl-4-methyl-3-phenylisoxazole

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 189.090211983
• Heavy Atom Count: 14
• Complexity: 182

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(ON=C1C2=CC=CC=C2)NN

Technology Process of 5-Hydrazinyl-4-methyl-3-phenylisoxazole

There total 1 articles about 5-Hydrazinyl-4-methyl-3-phenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bomo-4-methyl-3-phenylisoxazole (3477-03-0) → 5-hydrazino-4-methyl-3-phenyl-isoxazole (25388-07-2)

Guidance literature:

With hydrazine; at 100 ℃; for 0.416667h;

Reference yield: 10.0%

5-hydrazino-4-methyl-3-phenyl-isoxazole (25388-07-2) → 4-methyl-3-phenyl-1H-pyrazole (13808-62-3) + 4-methyl-3-phenyl-1H-pyrazol-5-amine (66367-67-7) + 2-amino-4-methyl-5-phenyl-1,2-dihydro-pyrazol-3-one (87389-78-4) + 1-amino-4-methyl-4-(4-methyl-5-phenyl-1H-pyrazol-3-ylamino)-3-phenyl-4,5-dihydro-1H-pyrazol-5-one

Guidance literature:

With hydrazine hydrate; at 115 ℃; for 3.5h; Further byproducts given;

DOI:10.1002/jhet.5570350120

Reference yield: 10.0%

5-hydrazino-4-methyl-3-phenyl-isoxazole (25388-07-2) → 4-methyl-3-phenyl-1H-pyrazole (13808-62-3) + 4-methyl-3-phenyl-1H-pyrazol-5-amine (66367-67-7) + 2-amino-4-methyl-5-phenyl-1,2-dihydro-pyrazol-3-one (87389-78-4) + 4-amino-4-methyl-5-phenyl-2,4-dihydro-pyrazol-3-one (63955-02-2)

Guidance literature:

With hydrazine hydrate; at 115 ℃; for 3.5h; Further byproducts given;

DOI:10.1002/jhet.5570350120

upstream raw materials:

5-bomo-4-methyl-3-phenylisoxazole

Downstream raw materials:

formaldehyde (4-methyl-3-phenyl-isoxazol-5-yl)-hydrazone

formic acid N'-(4-methyl-3-phenyl-isoxazol-5-yl)-hydrazide

benzaldehyde (4-methyl-3-phenyl-isoxazol-5-yl)-hydrazone

toluene-4-sulfonic acid N'-(4-methyl-3-phenyl-isoxazol-5-yl)-hydrazide