Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate

Base Information

Chemical Name:Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate
CAS No.:25518-39-2
Molecular Formula:C6H8F3NO3
Molecular Weight:199.12800
Hs Code.:2924199090
DSSTox Substance ID:DTXSID00401073
Nikkaji Number:J450.706A
Mol file:25518-39-2.mol

Synonyms:Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate;25518-39-2;2-(Trifluoroacetylamino)propionic acid methyl ester;ST51015136;SCHEMBL8944922;DTXSID00401073;JMVPNAUEPQEDJW-UHFFFAOYSA-N;AKOS010763260;FT-0638531

Suppliers and Price of Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate

Chemical Property:

PSA：58.89000
LogP:1.06670
Storage Temp.:2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:199.04562760
Heavy Atom Count:13
Complexity:214

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)OC)NC(=O)C(F)(F)F

Technology Process of Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate

There total 10 articles about Methyl 2-[(2,2,2-trifluoroacetyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1356449-87-0
calyxamide A

: 407-25-0
trifluoroacetic anhydride

: 1118-73-6,1607-08-5,25518-39-2,81131-19-3
N-trifluoroacetyl-L-alanine methyl ester

: 1808-42-0,1577-58-8,23635-22-5,29588-17-8,81131-21-7,81131-22-8,81131-23-9
(2S,3S)-methyl 3-methyl-2-(2,2,2-trifluoroacetamido)pentanoate

Guidance literature:: calyxamide A; With hydrogenchloride; water; at 110 ℃; for 24h;

methanol; With hydrogenchloride; In water; at 100 ℃; for 0.5h;

trifluoroacetic anhydride; In dichloromethane; water; at 100 ℃; for 0.0833333h;
DOI:10.1021/np2009187

Reference yield:

: 67-56-1
methanol

: 1356449-88-1
calyxamide B

: 407-25-0
trifluoroacetic anhydride

: 1118-73-6,1607-08-5,25518-39-2,81131-19-3
N-trifluoroacetyl-L-alanine methyl ester

: 1808-42-0,1577-58-8,23635-22-5,29588-17-8,81131-21-7,81131-22-8,81131-23-9
(2S,3S)-methyl 3-methyl-2-(2,2,2-trifluoroacetamido)pentanoate

Guidance literature:: calyxamide B; With hydrogenchloride; water; at 110 ℃; for 24h;

methanol; With hydrogenchloride; In water; at 100 ℃; for 0.5h;

trifluoroacetic anhydride; In dichloromethane; water; at 100 ℃; for 0.0833333h;
DOI:10.1021/np2009187

Reference yield:

: 67-56-1
methanol

: 1356449-87-0
calyxamide A

: 407-25-0
trifluoroacetic anhydride

: 1118-73-6,1607-08-5,25518-39-2,81131-19-3
N-trifluoroacetyl-L-alanine methyl ester

: 1808-42-0,1577-58-8,23635-22-5,29588-17-8,81131-21-7,81131-22-8,81131-23-9
(2S,3S)-methyl 3-methyl-2-(2,2,2-trifluoroacetamido)pentanoate

: 81083-58-1,81084-01-7,688-09-5
diethyl N-(2,2,2-trifluoroacetyl)-L-aspartate

: C₇H₁₀F₃NO₄

Guidance literature:: calyxamide A; With ozone; In methanol; at -78 ℃; for 0.25h;

With hydrogenchloride; water; at 110 ℃; for 24h;

methanol; trifluoroacetic anhydride; Further stages;
DOI:10.1021/np2009187