6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide

Base Information

• Chemical Name: 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide
• CAS No.: 1027408-38-3
• Molecular Formula: C₂₅H₂₃F₃N₂O
• Molecular Weight: 424.466
• Mol file: 1027408-38-3.mol

Synonyms:6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide

Chemical Property of 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide

There total 12 articles about 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester (391655-29-1) → 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide (1027408-38-3)

Guidance literature:

With trimethylsilyl iodide; In acetonitrile; at 20 ℃;

DOI:10.1021/jm010294e

Reference yield:

indan-2-ol (4254-29-9) → 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide (1027408-38-3)

Guidance literature:

Multi-step reaction with 8 steps

1: 90 percent / iPr₂NEt; DMAP / CH₂Cl₂ / 16.5 h

2: 49 percent / dimethylformamide / 3 h / 90 °C

3: 93 percent / LiAlH₄ / diethyl ether / 3 h

4: 71 percent / iPr₂NEt / CH₂Cl₂ / 1 h

5: 98 percent / fuming HNO₃; CF₃COOH / 3 h / 0 °C

6: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

7: 90 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

8: Me₃SiI / acetonitrile / 20 °C

With pyridine; dmap; lithium aluminium tetrahydride; trimethylsilyl iodide; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm010294e

Reference yield:

methansulfonic acid 2,3-dihydro-1H-inden-2-yl ester (777-72-0) → 6-methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid (2-aminomethyl-indan-5-yl)-amide (1027408-38-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 49 percent / dimethylformamide / 3 h / 90 °C

2: 93 percent / LiAlH₄ / diethyl ether / 3 h

3: 71 percent / iPr₂NEt / CH₂Cl₂ / 1 h

4: 98 percent / fuming HNO₃; CF₃COOH / 3 h / 0 °C

5: 82 percent / H₂ / 10percent Pd/C / ethyl acetate / 16 h / 20 °C / 2585.81 Torr

6: 90 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

7: Me₃SiI / acetonitrile / 20 °C

With pyridine; lithium aluminium tetrahydride; trimethylsilyl iodide; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 10percent Pd/C; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm010294e

upstream raw materials:

{5-[(6-methyl-4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indan-2-ylmethyl}-carbamic acid methyl ester

indan-2-ol

methansulfonic acid 2,3-dihydro-1H-inden-2-yl ester

1H-indene-2-methanamine, 2,3-dihydro