tert-Butyldimethyl(4-chlorobenzyloxy)silane

Base Information

Chemical Name:tert-Butyldimethyl(4-chlorobenzyloxy)silane
CAS No.:256521-85-4
Molecular Formula:C13H21ClOSi
Molecular Weight:256.848
Hs Code.:
DSSTox Substance ID:DTXSID201168114
Nikkaji Number:J1.225.874G
Mol file:256521-85-4.mol

Synonyms:256521-85-4;tert-Butyldimethyl(4-chlorobenzyloxy)silane;BDELLEROAYBJQQ-UHFFFAOYSA-N;DTXSID201168114;4-Chlorobenzyl alcohol, TBDMS derivative;tert-Butyl((4-chlorobenzyl)oxy)dimethylsilane;4-Chlorobenzyl alcohol, tert-butyldimethylsilyl ether;1-Chloro-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]benzene

Suppliers and Price of tert-Butyldimethyl(4-chlorobenzyloxy)silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-Butyldimethyl(4-chlorobenzyloxy)silane

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:256.1050195
Heavy Atom Count:16
Complexity:215

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC1=CC=C(C=C1)Cl

Technology Process of tert-Butyldimethyl(4-chlorobenzyloxy)silane

There total 3 articles about tert-Butyldimethyl(4-chlorobenzyloxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 873-76-7
para-Chlorobenzyl alcohol

: 256521-85-4
4-[(chlorophenyl)methoxy](1,1-dimethylethyl)dimethylsilane

Guidance literature:: With 1H-imidazole; In dichloromethane; for 3h;
DOI:10.1021/jo051747g

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: 256521-85-4
4-[(chlorophenyl)methoxy](1,1-dimethylethyl)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

2: sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux

3: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos; In 1,4-dioxane; dichloromethane; water; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ol300149b

Reference yield:

: 29540-84-9
4-chlorophenyl trifluoromethanesulfonate

: 256521-85-4
4-[(chlorophenyl)methoxy](1,1-dimethylethyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos / 1,4-dioxane; water / 5 h / Inert atmosphere; Reflux

2: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C

With 1H-imidazole; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos; In 1,4-dioxane; dichloromethane; water; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ol300149b