1-(2-Nitrophenyl)-1H-pyrazole

Base Information

• Chemical Name: 1-(2-Nitrophenyl)-1H-pyrazole
• CAS No.: 25688-17-9
• Molecular Formula: C9H7N3O2
• Molecular Weight: 189.173
• Hs Code.: 2933199090
• Mol file: 25688-17-9.mol

Synonyms:1H-Pyrazole,1-(2-nitrophenyl);1-(2'-nitrophenyl)pyrazole;1-(o-nitrophenyl)-pyrazole;(2-nitrophenyl)pyrazole;nitrophenylpyrazole;1-(2-nitrophenyl)pyrazol;1-(2-nitro-phenyl)-1H-pyrazole;

Chemical Property of 1-(2-Nitrophenyl)-1H-pyrazole

Chemical Property:

• Melting Point: 87-88 °C
• Boiling Point: 332.7±25.0 °C(Predicted)
• PKA: -0.69±0.10(Predicted)
• PSA: 63.64000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 2.30370
• Storage Temp.: Room temperature.

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2-Nitrophenyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Nitrophenyl)-1H-pyrazole

There total 13 articles about 1-(2-Nitrophenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

NH-pyrazole (288-13-1) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 1-(2-nitrophenyl)pyrazol (25688-17-9)

Guidance literature:

With hydrogen; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01105

Reference yield: 93.0%

NH-pyrazole (288-13-1) + o-nitroiodobenzene (609-73-4) → 1-(2-nitrophenyl)pyrazol (25688-17-9)

Guidance literature:

With pyridine; [Cu₂(pda)3(ReO₄)2]2*2H₂O; caesium carbonate; at 170 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.201100399

Reference yield: 91.0%

NH-pyrazole (288-13-1) + 1,2-Dinitrobenzene (528-29-0) → 1-(2-nitrophenyl)pyrazol (25688-17-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Catalytic behavior;

DOI:10.1039/d0nj05711h

upstream raw materials:

malondialdehyde bis(diethyl acetal)

o-nitrophenylhydrazine hydrochloride

1-(2-nitro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid

NH-pyrazole

Refernces

• 1、 Sirbu, Doina,Diharce, Julien,Martini?, Ivana,Chopin, Nicolas,Eliseeva, Svetlana V.,Guillaumet, Gérald,Petoud, Stéphane,Bonnet, Pascal,Suzenet, Franck. "An original class of small sized molecules as versatile fluorescent probes for cellular imaging". . p. 7776 - 7779. Retrieved 2019.
• 2、 Yan, Qi,Chen, Yuzhe,Tang, Baiyou,Xiao, Qiang,Qu, Rong,Tong, Linjiang,Liu, Jian,Ding, Jian,Chen, Yi,Ding, Ning,Tan, Wenfu,Xie, Hua,Li, Yingxia. "Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation". . p. 298 - 306. Retrieved 2018/05/22.