5-Ethoxy-2-phenyl-1,3-oxazole

Base Information

• Chemical Name: 5-Ethoxy-2-phenyl-1,3-oxazole
• CAS No.: 25755-93-5
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• DSSTox Substance ID: DTXSID40363409
• Nikkaji Number: J406.455K
• Wikidata: Q82147090
• Mol file: 25755-93-5.mol

Synonyms:5-ethoxy-2-phenyl-1,3-oxazole;25755-93-5;5-Ethoxy-2-phenyloxazole;2-phenyl-5-ethoxyoxazole;Bionet2_000745;RKLBGWCFWWLAOJ-UHFFFAOYSA-;DTXSID40363409;HMS1366B19;MFCD00793760;AKOS006271697;1M-032

Chemical Property of 5-Ethoxy-2-phenyl-1,3-oxazole

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CN=C(O1)C2=CC=CC=C2

Technology Process of 5-Ethoxy-2-phenyl-1,3-oxazole

There total 14 articles about 5-Ethoxy-2-phenyl-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl hippurate (1499-53-2) → 5-ethoxy-2-phenyl-1,3-oxazole (25755-93-5)

Guidance literature:

ethyl hippurate; With phosphorus pentachloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 1h;

at 40 ℃; for 48h; Darkness;

DOI:10.1039/c8md00139a

Reference yield: 90.0%

diazoacetic acid ethyl ester (623-73-4) + benzonitrile (100-47-0) → 5-ethoxy-2-phenyl-1,3-oxazole (25755-93-5)

Guidance literature:

With montmorillonite; copper(l) chloride; at 135 ℃; Microwave irradiation;

DOI:10.3184/174751912X13298456741454

Reference yield: 75.0%

5-Ethoxy-2-phenyl-4-triethylsilyloxazole (284040-82-0) → 5-ethoxy-2-phenyl-1,3-oxazole (25755-93-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 6h; Heating;

upstream raw materials:

ethyl hippurate

ethyl-2-azidoacetate

Benzoyl bromide

glycine ethyl ester hydrochloride

Downstream raw materials:

2,5-diphenyl-7-carbethoxy-2,4,6,8-tetraaza <3.3.1>bicyclooct-5-ene-1,3-dione

1,2,5-tricarbethoxy-3-phenyl-Δ³-1,2,4-triazoline

ethyl N-benzoylcarbamate

(1R,7aS)-6-(4-Chloro-phenyl)-5,7-dioxo-3-phenyl-5,6,7,7a-tetrahydro-1H-imidazo[1,5-c]imidazole-1-carboxylic acid ethyl ester