5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE

Base Information

Chemical Name:5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE
CAS No.:156337-32-5
Molecular Formula:C₂₃H₂₅ClN₂O
Molecular Weight:380.917
Hs Code.:
Mol file:156337-32-5.mol

Synonyms:L 741742

Suppliers and Price of 5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
L-741,742hydrochloride ≥98%(HPLC)
10
$ 159.00

Tocris
L-741,742hydrochloride ≥98%(HPLC)
50
$ 658.00

American Custom Chemicals Corporation
5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLEHYDROCHLORIDE 95.00%
5MG
$ 499.15

Total 3 raw suppliers

Chemical Property of 5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE

Chemical Property:

Vapor Pressure:6.85E-11mmHg at 25°C
Boiling Point:519.4°Cat760mmHg
Flash Point:267.9°C
PSA：29.27000
Density:1.156g/cm³
LogP:6.46540
Storage Temp.:Store at RT

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

L-741,742hydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses L-741,742 Hydrochloride is a D4 dopamine receptor antagonist used in the treatment of psychological diseases such as depression, schizophrenia. Antipsychotic.

Technology Process of 5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE

There total 12 articles about 5-(4-CHLOROPHENYL)-4-METHYL-3-(1-(2-PHENYLETHYL)PIPERIDIN-4-YL)ISOXAZOLE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 156337-32-5
L-741742

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexanes, 2.) THF, hexanes, -78 deg C, 45 min

2: HCl in EtOAc / 1.) RT, 30 min, 2.) 0 deg C, 1 h

3: Et₃N / dimethylformamide; CH₂Cl₂ / 24 h

4: 1.) hydroxylamine hydrochloride, Eti-Pr₂N, 2.) Et₃N, methanesulfonyl chloride / 1.) EtOH, DMF, a ) RT, 16 h, b ) 50 deg C, 4 h, 2.) Ch₂Cl₂, 0 deg C, 1 h

With hydrogenchloride; hydroxylamine hydrochloride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970111h

Reference yield:

: 293744-38-4
tert-butyl 4-(1H-imindazole-1-carbonyl)piperidine-1-carboxylate

: 156337-32-5
L-741742

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexanes, 2.) THF, hexanes, -78 deg C, 45 min

2: HCl in EtOAc / 1.) RT, 30 min, 2.) 0 deg C, 1 h

3: Et₃N / dimethylformamide; CH₂Cl₂ / 24 h

4: 1.) hydroxylamine hydrochloride, Eti-Pr₂N, 2.) Et₃N, methanesulfonyl chloride / 1.) EtOH, DMF, a ) RT, 16 h, b ) 50 deg C, 4 h, 2.) Ch₂Cl₂, 0 deg C, 1 h

With hydrogenchloride; hydroxylamine hydrochloride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970111h

Reference yield:

: 4-[(Z)-3-(4-Chloro-phenyl)-1-hydroxy-2-methyl-3-oxo-propenyl]-piperidine-1-carboxylic acid tert-butyl ester

: 156337-32-5
L-741742

Guidance literature:: Multi-step reaction with 3 steps

1: HCl in EtOAc / 1.) RT, 30 min, 2.) 0 deg C, 1 h

2: Et₃N / dimethylformamide; CH₂Cl₂ / 24 h

3: 1.) hydroxylamine hydrochloride, Eti-Pr₂N, 2.) Et₃N, methanesulfonyl chloride / 1.) EtOH, DMF, a ) RT, 16 h, b ) 50 deg C, 4 h, 2.) Ch₂Cl₂, 0 deg C, 1 h

With hydrogenchloride; hydroxylamine hydrochloride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970111h