Urea, N-cyclohexyl-N'-(phenylmethyl)-

Base Information

• Chemical Name: Urea, N-cyclohexyl-N'-(phenylmethyl)-
• CAS No.: 25855-24-7
• Molecular Formula: C14H20N2O
• Molecular Weight: 232.326
• Mol file: 25855-24-7.mol

Synonyms:N-Benzyl-N'-cyclohexylharnstoff;N-benzyl-N'-cyclohexylurea;N'-benzyl-N-cyclohexylcarbamimidic acid;

Chemical Property of Urea, N-cyclohexyl-N'-(phenylmethyl)-

Chemical Property:

• PSA: 44.62000
• LogP: 3.41380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Urea, N-cyclohexyl-N'-(phenylmethyl)-

There total 37 articles about Urea, N-cyclohexyl-N'-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyl N-cyclohexylcarbamate (7107-58-6) + benzylamine (100-46-9) → N-benzyl-N'-cyclohexylurea (25855-24-7)

Guidance literature:

benzyl N-cyclohexylcarbamate; With diiodosilane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 - -5 ℃; for 0.5h;

benzylamine; In dichloromethane; at -50 - 20 ℃; Further stages.;

DOI:10.1021/jo9919714

Reference yield: 93.0%

N-tert-butoxycarbonylbenzylamine (42116-44-9) + cyclohexylamine (108-91-8,157973-60-9) → N-benzyl-N'-cyclohexylurea (25855-24-7)

Guidance literature:

cyclohexylamine; With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In toluene; at 40 ℃; for 0.333333h;

N-tert-butoxycarbonylbenzylamine; In toluene; at 90 ℃; for 2h;

DOI:10.1016/j.tet.2018.06.011

Reference yield: 92.0%

N-(benzyl)-1H-imidazole-1-carboxamide (109844-65-7) + cyclohexylamine (108-91-8,157973-60-9) → N-benzyl-N'-cyclohexylurea (25855-24-7)

Guidance literature:

With zirconium(IV) chloride; In tetrahydrofuran; for 2h; Reflux;

DOI:10.1002/bkcs.10646

upstream raw materials:

N-cyclohexyl-carbamate de succinimidyle

benzylamine

[bis(acetoxy)iodo]benzene

cyclohexylamine

Downstream raw materials:

N-((benzylimino)methylene)cyclohexanamine

N'-cyclohexylurea