Benzenepropanenitrile, 2-methyl-

Base Information

• Chemical Name: Benzenepropanenitrile, 2-methyl-
• CAS No.: 26016-32-0
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Mol file: 26016-32-0.mol

Synonyms:

Chemical Property of Benzenepropanenitrile, 2-methyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanenitrile, 2-methyl-

There total 8 articles about Benzenepropanenitrile, 2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trimethylsilyl cyanide (7677-24-9) + o-methylphenylacetic acid (644-36-0) → 3-(o-tolyl)propanenitrile (26016-32-0)

Guidance literature:

o-methylphenylacetic acid; With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane; iodine; In chloroform; at 60 ℃; Inert atmosphere;

trimethylsilyl cyanide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform; at 60 ℃; for 5h; Reagent/catalyst; chemoselective reaction; Inert atmosphere;

DOI:10.1055/s-0033-1339903

Reference yield: 79.0%

Isovaleronitrile (625-28-5) + 1-methyl-2-vinyl-benzene (611-15-4) → 2-(2-methylphenyl)propanenitrile (58422-60-9) + 3-(o-tolyl)propanenitrile (26016-32-0)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; dimethylaluminum chloride; bis[2-(diphenylphosphino)phenyl] ether; In hexane; toluene; at 100 ℃; for 16h; Schlenk technique; Inert atmosphere; Glovebox;

Reference yield: 76.0%

diethyl 1-cyanomethylphosphonate (2537-48-6) + 2-methylphenyl aldehyde (529-20-4) → 3-(o-tolyl)propanenitrile (26016-32-0)

Guidance literature:

With lithium methanolate; ammonia; lithium perchlorate; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Electrochemical reaction;

DOI:10.1021/acs.joc.1c01024

upstream raw materials:

trimethylsilyl cyanide

o-methylphenylacetic acid

Isovaleronitrile

1-methyl-2-vinyl-benzene

Downstream raw materials:

3-(2-Methylphenyl)propylamine

7-Amino-6-nitro-2-(2-o-tolyl-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-Hydroxy-6-nitro-2-(2-o-tolyl-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

7-Chloro-6-nitro-2-(2-o-tolyl-ethyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one