5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 26028-36-4
• Molecular Formula: C10H7BrO3
• Molecular Weight: 255.068
• Hs Code.: 2932999099
• Mol file: 26028-36-4.mol

Synonyms:Methyl 5-bromobenzofuran-2-carboxylate;methyl 5-bromo-1-benzofuran-2-carboxylate;

Chemical Property of 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000459mmHg at 25°C
• Boiling Point: 314.7oC at 760 mmHg
• Flash Point: 144.1oC
• PSA: 39.44000
• Density: 1.589g/cm3
• LogP: 2.98190
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromobenzofuran-2-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromobenzofuran-2-carboxylic acid methyl ester is used in the synthesis of biscationic, trypanocidal 1-benzofuran compounds.

Technology Process of 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER

There total 10 articles about 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 5-bromobenzo[b]furan-2-carboxylic acid (10242-11-2) → 5-bromo-2-benzofurancarboxylic acid methyl ester (26028-36-4)

Guidance literature:

With sulfuric acid; for 15h; Heating;

Reference yield: 90.6%

acetylene dibromide (624-61-3) + Kohlensaeure-<4-brom-phenyl>-methyl-ester (1847-93-4) → 5-bromo-2-benzofurancarboxylic acid methyl ester (26028-36-4)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; for 8h; Cooling with ice;

Reference yield: 76.0%

methanol (67-56-1) + 4-bromobenzofuran-2-carboxylic acid (1369143-28-1) → 5-bromo-2-benzofurancarboxylic acid methyl ester (26028-36-4)

Guidance literature:

With thionyl chloride; at 0 - 60 ℃; for 4h;

upstream raw materials:

methanol

5-bromobenzo[b]furan-2-carboxylic acid

methyl (4-bromo-2-formylphenoxy)acetate

5-bromosalicyclaldehyde

Downstream raw materials:

methyl 5-cyanobenzofuran-2-carboxylate

5-bromo-2-(hydroxymethyl)-1-benzofuran

5-cyanobenzo[b]furan-2-carboxylic acid

2-<(E)-4-Cyanstyryl>-1-benzofuran-5-carbonitril