2-(2,4-Difluorophenoxy)-1-(4-methylsulfanyl phenyl)ethanone

Base Information

• Chemical Name: 2-(2,4-Difluorophenoxy)-1-(4-methylsulfanyl phenyl)ethanone
• CAS No.: 263242-00-8
• Molecular Formula: C15H12F2O2S
• Molecular Weight: 294.322
• DSSTox Substance ID: DTXSID10458477
• Wikidata: Q82281760

Synonyms:2-(2,4-Difluorophenoxy)-1-(4-methylsulfanyl phenyl)ethanone;263242-00-8;SCHEMBL3973566;DTXSID10458477;ZHYFMSAURZABER-UHFFFAOYSA-N;AKOS008954671

Chemical Property of 2-(2,4-Difluorophenoxy)-1-(4-methylsulfanyl phenyl)ethanone

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 294.05260712
• Heavy Atom Count: 20
• Complexity: 319

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSC1=CC=C(C=C1)C(=O)COC2=C(C=C(C=C2)F)F

Technology Process of 2-(2,4-Difluorophenoxy)-1-(4-methylsulfanyl phenyl)ethanone

There total 1 articles about 2-(2,4-Difluorophenoxy)-1-(4-methylsulfanyl phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,4-difluorophenol (367-27-1) + 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone (42445-46-5) → 2-(2,4-difluorophenoxy)-1-(4-methylsulfanyl)ethanone (263242-00-8)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm049882t

Reference yield: 89.0%

2-(2,4-difluorophenoxy)-1-(4-methylsulfanyl)ethanone (263242-00-8) → 2-(2,4-difluorophenoxy)-1-(4-methanesulfonylphenyl)ethanone (263242-01-9)

Guidance literature:

With magnesium monoperoxyphthalate hexahydrate; In dichloromethane; water; at 20 ℃; for 16h;

Reference yield: 17.0%

2-(2,4-difluorophenoxy)-1-(4-methylsulfanyl)ethanone (263242-00-8) → 3-(2,4-difluorophenoxy)-6-methyl-2-[4-(methylthio)phenyl]-4H-pyran-4-one (746624-40-8)

Guidance literature:

With PPA; In acetic anhydride; at 95 - 100 ℃; for 5h;

upstream raw materials:

2,4-difluorophenol

2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone

Downstream raw materials:

2-(2,4-difluorophenoxy)-1-(4-methanesulfonylphenyl)ethanone

3-(2,4-difluorophenoxy)-6-methyl-2-[4-(methylthio)phenyl]-4H-pyran-4-one

3-(2,4-difluorophenoxy)-2-(4-methanesulfonylphenyl)-6-methylpyran-4-one

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