Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester

Base Information

• Chemical Name: Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester
• CAS No.: 143331-46-8
• Molecular Formula: C₆₁H₆₁N₄O₁₁P
• Molecular Weight: 1057.15

Synonyms:

Chemical Property of Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester

There total 2 articles about Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dichloroisopropylphosphine (25235-15-8) + 5'-O-tritylthymidine (7791-71-1) → Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester (143331-46-8)

Guidance literature:

With 2,3,5-trimethyl-pyridine; tert.-butylhydroperoxide; Multistep reaction; 1) THF, 4 deg C, 2) 4 deg C, 10 min;

Reference yield:

dichloroisopropylphosphine (25235-15-8) + 5'-O-tritylthymidine (7791-71-1) + 3'-O-(t-butyldimethylsilyl)thymidine (40733-27-5) → Isopropyl-phosphonic acid bis-[(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester (143331-46-8) + C48H61N4O11PSi + C48H61N4O11PSi

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

dichloroisopropylphosphine

5'-O-tritylthymidine

3'-O-(t-butyldimethylsilyl)thymidine

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