1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid

Base Information

Chemical Name:1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid
CAS No.:264273-07-6
Molecular Formula:C24H19NO4
Molecular Weight:385.419
Hs Code.:
European Community (EC) Number:847-130-1,857-396-0
DSSTox Substance ID:DTXSID20405730

Synonyms:1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid;Fmoc-DL-Idc-OH;198560-38-2;264273-07-6;1-(9H-fluoren-9-ylmethoxycarbonyl)-2,3-dihydroindole-2-carboxylic Acid;1-{[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;SCHEMBL6369767;AMY4546;DTXSID20405730;AKOS016009918;EN300-814201;J-012830

Suppliers and Price of 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:385.13140809
Heavy Atom Count:29
Complexity:614

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(N(C2=CC=CC=C21)C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)C(=O)O

Technology Process of 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid

There total 4 articles about 1-(((9H-Fluoren-9-yl)methoxy)carbonyl)indoline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 16851-56-2,78348-24-0
indolin-2-yl carboxylic acid

: 264273-07-6,198560-38-2
2,3-dihydro-indole-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With sodium carbonate; In 1,4-dioxane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm049906w

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 264273-07-6,198560-38-2
2,3-dihydro-indole-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / H₂SO₄ / 6 h / Heating

2: 74 percent / Mg; MeOH / 20 °C

3: aq. KOH / methanol / 20 °C

4: 422 mg / aq. Na₂CO₃ / dioxane / 2 h / 0 - 20 °C

With methanol; potassium hydroxide; sulfuric acid; sodium carbonate; magnesium; In 1,4-dioxane; methanol;
DOI:10.1021/jm049906w

Reference yield:

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 264273-07-6,198560-38-2
2,3-dihydro-indole-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / Mg; MeOH / 20 °C

2: aq. KOH / methanol / 20 °C

3: 422 mg / aq. Na₂CO₃ / dioxane / 2 h / 0 - 20 °C

With methanol; potassium hydroxide; sodium carbonate; magnesium; In 1,4-dioxane; methanol;
DOI:10.1021/jm049906w