Flubromazepam

Base Information

• Chemical Name: Flubromazepam
• CAS No.: 2647-50-9
• Molecular Formula: C15H10BrFN2O
• Molecular Weight: 333.16
• Hs Code.: 2933990090
• Mol file: 2647-50-9.mol

Synonyms:2H-1,4-Benzodiazepin-2-one,7-bromo-5-(2-fluorophenyl)-1,3-dihydro;7-Brom-5-<2-fluor-phenyl>-1.3-dihydro-2H-1.4-benzodiazepin-2-on;7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Brom-5-<2-fluor-phenyl>-2-oxo-1,2-dihydro-<1,4>benzodiazepin;7-bromo-5-(2-fluoro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one;7-Brom-5-<2-fluor-phenyl>-3H-1,4-benzodiazepin-2(1H)-on;7-bromo-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one;7-bromo-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Flubromazepam

Chemical Property:

• Melting Point: 189-190℃
• Boiling Point: 465.7±45.0 °C(Predicted)
• PKA: 11.55±0.70(Predicted)
• PSA: 44.95000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: 2.89840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Flubromazepam is a designer benzodiazepine drug structurally related to Phenazepam ; a drug used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. Phenazepam can also be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. Flubromazepam is a potent, long-acting novel psychoactive benzodiazepine with anxiolytic, anticonvulsant, muscle relaxant and hypnotic properties. Flubromazepam reportedly has a high addiction potential and risk of overdose. This certified Snap-N-Spike? solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
• Description: Flubromazepam (Item No. 15157) is an analytical reference standard categorized as a benzodiazepine. Flubromazepam has been detected in seized samples and has anxiolytic and sedative properties. This product is intended for research and forensic applications.

Technology Process of Flubromazepam

There total 8 articles about Flubromazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.8%

5-bromo-2-bromoacetamido-2'-fluorobenzophenone (1647-74-1) → 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (2647-50-9)

Guidance literature:

With ammonia; In methanol; for 16h; Heating / reflux;

Reference yield:

→ 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (2647-50-9)

Guidance literature:

2-Amino-5-brom-2'-fluor-benzophenon, 3 Aequ. Glycin-ethylester-hydrochlorid, Pyridin (Piperidin), Kochen;

Reference yield:

5-bromo-2'-fluoro-2-aminobenzophenone (1479-58-9) + 2-Bromoacetyl bromide (598-21-0) → 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (2647-50-9)

Guidance literature:

5-bromo-2'-fluoro-2-aminobenzophenone; 2-Bromoacetyl bromide; With sodium hydrogencarbonate; In dichloromethane;

With ammonia; In methanol; Heating / reflux;

upstream raw materials:

5-bromo-2-bromoacetamido-2'-fluorobenzophenone

5-bromo-2'-fluoro-2-aminobenzophenone

2-Bromoacetyl bromide

N⁽¹⁾-[4-bromo-2-[(2-fluorophenyl)carbonyl]phenyl]glycinamide

Downstream raw materials:

7-bromo-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

7-bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one

7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide

flubromazolam

Refernces

• 1、 Allred, B. McKay,France, Stefan,Jones, Lonnie V.,Ligon, Evelyn S.,Nawyn, Jason,Reinhardt, Daniel V.. "Synthesis of Flubromazepam Positional Isomers for Forensic Analysis". . . Retrieved 2019/08/26.
• 2、 -. "Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects". Page/Page column 30. . Retrieved 2008/06/13.