1647-74-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is used as an intermediate in the synthesis of Haloxazolam (H104000), a sleep-inducing agent. It is structurally related to other sedative and hypnotic drugs such as Oxazolam and Cloxazolam (C587475). The compound contributes to the development of medications that help alleviate insomnia and promote relaxation.
As a sedative and hypnotic agent, 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is used for its calming effects on the central nervous system. It is particularly useful in treating conditions such as anxiety and insomnia, where a controlled substance is required to induce sleep and reduce anxiety levels.
Furthermore, 2-Bromo-N-[4-bromo-2-(2-fluorobenzoyl)phenyl]acetamide is also used as a controlled substance (depressant) due to its potential for abuse and dependence. Its use is regulated to ensure that it is prescribed and administered responsibly, minimizing the risk of misuse and addiction.

Upstream product

• 1479-58-9 5-bromo-2'-fluoro-2-aminobenzophenone 
• 598-21-0 2-Bromoacetyl bromide 
• 304854-54-4 2-amino-5-bromo-N-methoxy-N-methyl-benzamide 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 74189-16-5 2-amino-5-bromobenzoic acid hydrochloride 

Downstream Products

• 10329-38-1 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 4-oxide 
• 62659-65-8 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one 
• 2647-50-9 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 

Relevant academic research and scientific papers

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

Synthesis of Flubromazepam Positional Isomers for Forensic Analysis

Designer benzodiazepines have recently appeared in many forensic cases as legal alternatives to federally scheduled drugs such as diazepam (Valium) and alprazolam (Xanax). Though current forensic instrumental techniques are often sufficient for identifying novel psychoactive substances, they may not readily differentiate between potential positional isomers. Additionally, characterization data for positional isomers of known designer benzodiazepines are widely nonexistent. In this study, flubromazepam, a recognized designer benzodiazepine since 2012, was targeted for synthesis and characterization due to its potential for federal scheduling and current legal status within the United States. A practical synthetic method was developed to prepare purified reference materials for each positional isomer of flubromazepam in which the positions of the bromine and fluorine substituents were varied. Possible isomers (9 of the 12) were successfully prepared and used for further analysis.

Carboxamide GABAa ALPHA2 Modulators

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.