4-BROMO-2,6-DIMETHOXYBENZENAMINE

Base Information

• Chemical Name: 4-BROMO-2,6-DIMETHOXYBENZENAMINE
• CAS No.: 23957-21-3
• Molecular Formula: C8H10 Br N O2
• Molecular Weight: 232.077
• Hs Code.: 2922299090
• Mol file: 23957-21-3.mol

Synonyms:Aniline,4-bromo-2,6-dimethoxy- (8CI); 4-Bromo-2,6-dimethoxyaniline; NSC 312015

Chemical Property of 4-BROMO-2,6-DIMETHOXYBENZENAMINE

Chemical Property:

• Vapor Pressure: 0.00399mmHg at 25°C
• Melting Point: 75-76 °C(Solv: ethanol (64-17-5))
• Boiling Point: 279.5°C at 760 mmHg
• PKA: 3.77±0.10(Predicted)
• Flash Point: 122.9°C
• PSA: 44.48000
• Density: 1.488g/cm³
• LogP: 2.62970

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2,6-dimethoxyaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2,6-DIMETHOXYBENZENAMINE

There total 4 articles about 4-BROMO-2,6-DIMETHOXYBENZENAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,6-dimethoxyaniline (2734-70-5) → 4-bromo-2,6-dimethoxyaniline (23957-21-3)

Guidance literature:

With bromine; In chloroform; at 0 - 21 ℃; for 14h;

DOI:10.3390/molecules26133916

Reference yield: 57.0%

5-bromo-1,3-dimethoxy-2-nitrobenzene (815632-47-4) → 4-bromo-2,6-dimethoxyaniline (23957-21-3)

Guidance literature:

With iron; ammonium chloride; In methanol; water; at 80 ℃; for 4h;

DOI:10.1021/ja402220t

Reference yield:

1-bromo-3,5-dimethoxybenzene (20469-65-2) → 4-bromo-2,6-dimethoxyaniline (23957-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride; nitric acid / 0 - 20 °C

2: ammonium chloride; iron / water; methanol / 4 h / 80 °C

With nitric acid; acetic anhydride; iron; ammonium chloride; In methanol; water;

DOI:10.1021/ja402220t

upstream raw materials:

5-bromo-1,3-dimethoxy-2-nitrobenzene

2,6-dimethoxyaniline

1-bromo-3,5-dimethoxybenzene

Downstream raw materials:

N-(4-Bromo-2,6-dimethoxy-phenyl)-3,3-dimethyl-butanamide

5-bromo-2-iodo-1,3-dimethoxy-benzene

(E)-1,2-bis(4-bromo-2,6-dimethoxyphenyl)diazene

5-bromo-2-chloro-1,3-dimethoxybenzene

Refernces

• 1、 Chen, Mingzhao,Jiang, Zhilong,Jiang, Zhiyuan,Li, Kaixiu,Li, Suqing,Liu, Die,Lou, Dongyang,Sun, Xiaoyi,Wang, Guotao,Wang, Jun,Wang, Pingshan,Wu, Tun,Zhao, He. "Reinforced Topological Nanoassemblies: 2D Hexagon-Fused Wheel to 3D Prismatic Metallo-Lamellar Structure with Molecular Weight of 119 K Daltons". supporting information. p. 7690 - 7698. Retrieved 2020/08/05.
• 2、 -. "ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF". Paragraph 0881. . Retrieved 2019/11/28.