Methyl 2-[(pyridin-4-ylmethyl)amino]benzoate

Base Information

• Chemical Name: Methyl 2-[(pyridin-4-ylmethyl)amino]benzoate
• CAS No.: 267891-88-3
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• DSSTox Substance ID: DTXSID301197336
• Mol file: 267891-88-3.mol

Synonyms:methyl 2-[(pyridin-4-ylmethyl)amino]benzoate;267891-88-3;Methyl 2-(pyridin-4-ylmethylamino)benzoate;Benzoic acid, 2-[(4-pyridinylmethyl)amino]-, methyl ester;methyl 2-([pyridin-4-ylmethyl]amino)benzoate;SCHEMBL1714816;GMNHZZBEKCHKJE-UHFFFAOYSA-N;DTXSID301197336;AKOS005877305;methyl N-(4-pyridylmethyl)-anthranilate;methyl 2-[(4-pyridylmethyl)amino]benzoate;2-[(pyridin-4-ylmethyl)-amino]-benzoic acid methyl ester

Chemical Property of Methyl 2-[(pyridin-4-ylmethyl)amino]benzoate

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C1=CC=CC=C1NCC2=CC=NC=C2

Technology Process of Methyl 2-[(pyridin-4-ylmethyl)amino]benzoate

There total 4 articles about Methyl 2-[(pyridin-4-ylmethyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

pyridine-4-carbaldehyde (872-85-5) + 2-carbomethoxyaniline (134-20-3) → methyl 2?([pyridin?4?ylmethyl]amino)benzoate (267891-88-3)

Guidance literature:

With sodium cyanoborohydride; In methanol;

DOI:10.1016/j.bmcl.2006.07.075

Reference yield:

2-{[1-Pyridin-4-yl-meth-(E)-ylidene]-amino}-benzoic acid methyl ester (385396-74-7) → methyl 2?([pyridin?4?ylmethyl]amino)benzoate (267891-88-3)

Guidance literature:

With sodium cyanoborohydride; In methanol; for 2h;

DOI:10.1021/jm020899q

Reference yield:

2-carbomethoxyaniline (134-20-3) → methyl 2?([pyridin?4?ylmethyl]amino)benzoate (267891-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / methanol / 18 h / 20 °C

2: 1.8 g / NaCNBH₃ / methanol / 2 h

With sodium cyanoborohydride; acetic acid; In methanol;

DOI:10.1021/jm020899q

upstream raw materials:

2-{[1-Pyridin-4-yl-meth-(E)-ylidene]-amino}-benzoic acid methyl ester

pyridine-4-carbaldehyde

2-carbomethoxyaniline

Downstream raw materials:

2?([pyridin?4?ylmethyl]amino)benzoic acid

2-(1-piperazinylcarbonyl)-N-(4-pyridinylmethyl)aniline