1-tert-Butyl-3-phenylaziridin-2-one

Base Information

• Chemical Name: 1-tert-Butyl-3-phenylaziridin-2-one
• CAS No.: 27151-60-6
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Hs Code.: 2933790090
• Mol file: 27151-60-6.mol

Synonyms:1-tert-butyl-3-phenylaziridinone;1-t-butyl-3-phenylaziridin-2-one;1-tert-Butyl-3-phenyl-2-aziridinone;2-Aziridinone,1-tert-butyl-3-phenyl;1-tert-butyl-3-phenyl-aziridin-2-one;N-tert-butyl-3-phenylaziridinone;Aziridinone,1-(1,1-dimethylethyl)-3-phenyl;1-tert-Butyl-3-phenyl-aziridinon;

Chemical Property of 1-tert-Butyl-3-phenylaziridin-2-one

Chemical Property:

• Melting Point: 32-33 °C
• Boiling Point: 268.9±43.0 °C(Predicted)
• PKA: -3.61±0.40(Predicted)
• PSA: 20.08000
• Density: 1.105±0.06 g/cm3(Predicted)
• LogP: 2.30630

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-tert-Butyl-3-phenylaziridin-2-one

There total 6 articles about 1-tert-Butyl-3-phenylaziridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-phenylacetyl-N-tert-butylhydroxylamine (68872-03-7) → 1-t-butyl-3-phenylaziridin-2-one (27151-60-6)

Guidance literature:

With trifluoromethylsulfonic anhydride; triethylamine; In dichloromethane; at -70 ℃;

DOI:10.1039/c39820001402

Reference yield: 65.0%

2-bromo-N-(tert-butyl)-2-phenylacetamide (55341-86-1) → 1-t-butyl-3-phenylaziridin-2-one (27151-60-6)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1021/jo020246h

Reference yield:

bromo(phenyl)acetyl chloride (19078-72-9) → 1-t-butyl-3-phenylaziridin-2-one (27151-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / CH₂Cl₂

2: 55 percent / potassium tert-butoxide / diethyl ether / 1 h / 0 °C

With potassium tert-butylate; In diethyl ether; dichloromethane;

DOI:10.1021/jo00350a014

upstream raw materials:

N-phenylacetyl-N-tert-butylhydroxylamine

2-bromo-N-(tert-butyl)-2-phenylacetamide

bromo(phenyl)acetyl chloride

phenylacetyl chloride

Downstream raw materials:

2-tert-butyl-3-phenyloxaziridine

N-tert-butylphenylacetamide

N-benzyl-N-tert-butyl-2-phenylacetamide

N-tert-butyl-2-phenyl-2-o-tolylacetamide