Oxazolo[4,5-C]pyridine

Base Information

• Chemical Name: Oxazolo[4,5-C]pyridine
• CAS No.: 273-56-3
• Molecular Formula: C6H4N2O
• Molecular Weight: 120.111
• DSSTox Substance ID: DTXSID30562782
• Nikkaji Number: J314.583B
• Wikidata: Q82447058
• Mol file: 273-56-3.mol

Synonyms:OXAZOLO[4,5-C]PYRIDINE;273-56-3;[1,3]oxazolo[4,5-c]pyridine;MFCD08692337;SCHEMBL89836;DTXSID30562782;ZATXVRSLQDRAHZ-UHFFFAOYSA-N;AKOS030632908;DS-19721;SY129985;CS-0160329;C74415;A918387

Chemical Property of Oxazolo[4,5-C]pyridine

Chemical Property:

• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 120.032362755
• Heavy Atom Count: 9
• Complexity: 107

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC2=C1OC=N2

Technology Process of Oxazolo[4,5-C]pyridine

There total 5 articles about Oxazolo[4,5-C]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-aminopyridin-4-ol (6320-39-4) + trimethyl orthoformate (149-73-5) → oxazolo[4,5-c]pyridine (273-56-3)

Guidance literature:

With acetic acid; at 160 ℃; for 0.5h; Microwave irradiation;

Reference yield: 35.0%

3-aminopyridin-4-ol (6320-39-4) + diethoxymethyl acetate (14036-06-7) → oxazolo[4,5-c]pyridine (273-56-3)

Guidance literature:

at 110 ℃; for 4h;

DOI:10.1002/jhet.5570270316

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → oxazolo[4,5-c]pyridine (273-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethanol

2: 35 percent / 4 h / 110 °C

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570270316

upstream raw materials:

N-(4-hydroxy-[3]pyridyl)-formamide

3-aminopyridin-4-ol

diethoxymethyl acetate

4-hydroxy-3-nitropyridine