2-(2-Methoxyphenyl)acetophenone

Base Information

• Chemical Name: 2-(2-Methoxyphenyl)acetophenone
• CAS No.: 27356-33-8
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID60435339
• Nikkaji Number: J371.277J
• Mol file: 27356-33-8.mol

Synonyms:2-(2-METHOXYPHENYL)ACETOPHENONE;27356-33-8;2-(2-methoxyphenyl)-1-phenylethanone;MFCD02260690;2-(2-methoxy-phenyl)-1-phenyl-ethanone;2-(2-methoxyphenyl)-1-phenyl-ethanone;2'-Methoxydeoxybenzoin;SCHEMBL597834;DTXSID60435339;WBBRMSBBDPOPOS-UHFFFAOYSA-N;AKOS009339053;2-(2-methoxyphenyl)-1-phenylethan-1-one

Chemical Property of 2-(2-Methoxyphenyl)acetophenone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 104 °C
• Boiling Point: 350.849oC at 760 mmHg
• Flash Point: 153.709oC
• PSA: 26.30000
• Density: 1.1g/cm3
• LogP: 3.12060
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 243

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Methoxyphenyl)acetophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1CC(=O)C2=CC=CC=C2

Technology Process of 2-(2-Methoxyphenyl)acetophenone

There total 35 articles about 2-(2-Methoxyphenyl)acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Chloroanisole (766-51-8) + acetophenone (98-86-2) → 2-(2-methoxyphenyl)-1-phenylethan-1-one (27356-33-8)

Guidance literature:

With C₄₁H₅₀ClN₃Pd; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1016/j.tetlet.2020.152124

Reference yield: 98.0%

2-methoxybenzil (34082-43-4) → 2-(2-methoxyphenyl)-1-phenylethan-1-one (27356-33-8)

Guidance literature:

2-methoxybenzil; With sodium iodide; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere; Green chemistry;

With chloro-trimethyl-silane; In dichloromethane; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.6b01491

Reference yield: 86.0%

2-methylmethoxybenzene (578-58-5) + N,N-diisopropyl benzamide (20383-28-2) → 2-(2-methoxyphenyl)-1-phenylethan-1-one (27356-33-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 60 ℃; for 12h;

DOI:10.1007/s11426-021-1035-5

upstream raw materials:

2-(1-phenylvinyl)anisole

2-amino-1-(2-methoxy-phenyl)-1-phenyl-ethanol

2-(2-hydroxyphenyl)-1-phenylethan-1-one

dimethyl sulfate

Downstream raw materials:

2'-methoxy-deoxybenzoin semicarbazone

2-(2-methoxyphenyl)-N-<2-(2-methoxyphenyl)-1-phenylethylidene>-1-phenylethanamine

3-Dimethylamino-2-(2-methoxy-phenyl)-1-phenyl-propan-1-one

1,3-diphenyl-4-orthomethoxyphenyl pyrazole

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