3,4-Dimethoxy-N,N-dimethylaniline

Base Information

• Chemical Name: 3,4-Dimethoxy-N,N-dimethylaniline
• CAS No.: 2748-79-0
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• DSSTox Substance ID: DTXSID30601786
• Nikkaji Number: J1.844.589A
• Wikidata: Q82498607
• Mol file: 2748-79-0.mol

Synonyms:3,4-Dimethoxy-N,N-dimethylaniline;2748-79-0;SCHEMBL1107760;DTXSID30601786;OJSINGAPXRDNSN-UHFFFAOYSA-N;5-Amino-2-methoxyphenol, N,N-methyl-, methyl ether

Chemical Property of 3,4-Dimethoxy-N,N-dimethylaniline

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC(=C(C=C1)OC)OC

Technology Process of 3,4-Dimethoxy-N,N-dimethylaniline

There total 5 articles about 3,4-Dimethoxy-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,4-dimethoxyaniline (6315-89-5) → 3,4-dimethoxy-N,N-dimethylaniline (2748-79-0)

Guidance literature:

With hydrogenchloride; Zr(BH₄)2Cl₂(dabco)2; In methanol; water; for 1.5h; Heating;

DOI:10.1246/bcsj.76.143

Reference yield: 72.0%

dimethyl sulfoxide (67-68-5,8070-53-9) + 3,4-dimethoxyaniline (6315-89-5) → 3,4-dimethoxy-N,N-dimethylaniline (2748-79-0)

Guidance literature:

With formic acid; triethylamine; at 150 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/chem.201303802

Reference yield:

3,4-dimethoxyaniline (6315-89-5) + methyl iodide (74-88-4) → 3,4-dimethoxy-N,N-dimethylaniline (2748-79-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water;

DOI:10.1016/j.tetlet.2016.02.111

upstream raw materials:

3,4-dimethoxynitrobenzene

formaldehyd

3,4-dimethoxyaniline

dimethyl sulfoxide

Downstream raw materials:

4-amino-1,2-benzenediol

4-Amino-2-hydroxy-1-methylamino-benzol