L-THIOPROLINE

Base Information

• Chemical Name: L-THIOPROLINE
• CAS No.: 2756-91-4
• Molecular Formula: C5H9NOS
• Mol file: 2756-91-4.mol

Synonyms:

Chemical Property of L-THIOPROLINE

Chemical Property:

• Vapor Pressure: 0.15mmHg at 25°C

Purity/Quality:

97% ^*data from raw suppliers

Thiazolidine-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-THIOPROLINE

There total 27 articles about L-THIOPROLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + L-Cysteine (52-90-4) → L-thioproline (34592-47-7,2756-91-4,6070-92-4,60731-25-1)

Guidance literature:

at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(00)00511-1

Reference yield: 93.5%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + rac-cysteine (921-01-7,3374-22-9,4371-52-2,40143-64-4,40143-66-6,40143-69-9,52-90-4) → (RS)-4-thiazolidinecarboxylic acid (444-27-9,19291-02-2,34592-47-7,45521-09-3,2756-91-4,6070-92-4,60731-25-1)

Guidance literature:

In water; acetic acid; at 30 ℃; for 1h;

DOI:10.1246/bcsj.62.109

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + l-cysteine hydrochloride (52-89-1) → L-thioproline (34592-47-7,2756-91-4,6070-92-4,60731-25-1)

Guidance literature:

With potassium acetate; In ethanol; water; at 20 - 90 ℃; for 2h;

DOI:10.1248/cpb.47.950

upstream raw materials:

formaldehyd

l-cysteine hydrochloride

(RS)-4-thiazolidinecarboxylic acid

DL-cysteine hydrochloride

Downstream raw materials:

(4R)-3-<(2S)-S-benzoyl-2-mercaptopropanoyl>-4-thiazolidinecarboxylic acid

Z-Gly-P(S)

N-(tert-butoxycarbonyl)-(R)-thiazolidine-4-carboxylic acid

(4R)-3-(S-benzoylmercaptoacetyl)-4-thiazolidinecarboxylic acid