2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-

Base Information

Chemical Name:2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-
CAS No.:27664-11-5
Molecular Formula:C19H17NO2
Molecular Weight:291.349
Hs Code.:
DSSTox Substance ID:DTXSID20387365
Mol file:27664-11-5.mol

Synonyms:27664-11-5;2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-;DTXSID20387365

Suppliers and Price of 2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:291.125928785
Heavy Atom Count:22
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C2=CC=CC=C21)C=CC(=O)C3=CC=C(C=C3)OC

Technology Process of 2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-

There total 6 articles about 2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 38470-69-8,22883-29-0
3-(1'H-indol-3'-yl)-1-(4-methoxyphenyl)-prop-2-en-1-one

: 74-88-4
methyl iodide

: 27664-11-5
1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one

Guidance literature:: 3-(1'H-indol-3'-yl)-1-(4"-methoxyphenyl)-prop-2-en-1-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; mineral oil;
DOI:10.1080/14756366.2022.2032688

Reference yield: 31.0%

: 19012-03-4
N-methyl-3-formylindole

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 27664-11-5
1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one

Guidance literature:: With potassium hydroxide; In ethanol; water; at 60 ℃;
DOI:10.1021/jm2016528

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 27664-11-5
1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 24 h / 0 - 20 °C

2.1: potassium hydroxide / ethanol / 24 h / 20 °C

With sodium hydride; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1039/c5ra28141e