1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-, 1,1-dimethylethyl ester
CAS No.:276872-81-2
Molecular Formula:C17H24FNO2
Molecular Weight:293.381
Hs Code.:2933399090
Mol file:276872-81-2.mol

Synonyms:tert-butyl 1-[4-(4-fluorobenzyl)piperidin-1-yl]carboxylate;4-[(4-fluorophenyl)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;4-(4-FLUORO-BENZYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-(t-butoxycarbonyl)-4-(4-fluorophenylmethyl)piperidine;1-tert-butoxycarbonyl-4-(4-fluorobenzyl)-piperidine;tert-butyl 4-(4-fluorobenzyl)piperidine-1-carboxylate;

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：29.54000
LogP:3.95320

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-, 1,1-dimethylethyl ester

There total 7 articles about 1-Piperidinecarboxylic acid, 4-[(4-fluorophenyl)methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 276872-81-2
N-(t-butoxycarbonyl)-4-(4-fluorophenylmethyl)piperidine

Guidance literature:: With hydrogen; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield: 90.7%

: 183951-17-9
4-(4-Fluorobenzylidene)piperidine-1-carboxylic acid tert-butyl ester

: 276872-81-2
N-(t-butoxycarbonyl)-4-(4-fluorophenylmethyl)piperidine

Guidance literature:: With palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;
DOI:10.1039/d1md00023c

Reference yield: 88.0%

: 159635-49-1
tert-butyl 4-methylidenepiperidine-1-carboxylate

: 460-00-4
1-Bromo-4-fluorobenzene

: 276872-81-2
N-(t-butoxycarbonyl)-4-(4-fluorophenylmethyl)piperidine

Guidance literature:: tert-butyl 4-methylidenepiperidine-1-carboxylate; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; for 1h; Reflux;

1-Bromo-4-fluorobenzene; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 65 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.03.013